2017/12/19 0:00:00 Zhang Zhi-Hong 6true in vivo. The liver is a vital organ for maintaining body’s metabolism and detoxification, and it as an immunological organ. Understanding the basic feature and function of liver immunology is significant for prevention and treatment of liver disease and associated systemic diseases. Visualization immune response under physiological or pathological condition in vivo, providing spatial-temporal and dynamic information of multiple cells involved in key events and their interactions, can greatly enrich the knowledge of liver unique immune response. This review will focus on the current liver intravital imaging techniques and methods, and the application of optical microscopic imaging techniques in liver immunology, such as multiphoton excitation confocal microscopy and spin-disk confocal microscopy, and future development directions and challenges of in vivo liver imaging are prospected.]]> 2017/12/19 0:00:00 LIN Qiao-Ya, HUANG Song-Lin, LUO Qing-Ming and ZHANG Zhi-Hong 5true 2017/12/19 0:00:00 LIN Wei and CHU Yi-Wei 4true 2017/12/19 0:00:00 CHANG Hao-Cai, ZHANG Zhen-Zhen and LIU Lei 3true +CD4⁺ T cells, CD3^-NK1.1⁺DX5^- NK cells, and CD11b⁺F4/80^-Ly6c⁺ cells were increased in the inflamed eye and liver. Furthermore, the pathological damage of EAU and hepatic impairment were aggravated after transferring CD3⁺CD4⁺ T cells into EAU mice. Additionally, vascular dilation and infiltration of CD3⁺CD4⁺ T cells were found in the eyes and livers of EAU mice. In conclusion, our findings suggest that liver injury could occur in EAU. This liver injury may be associated with increased CD3⁺CD4⁺ T cells, which may infiltrate into liver through circulatory system.]]> 2017/12/19 0:00:00 LIN Wei, SONG Nan-Nan, Wang Bei-Bei and BI Hong-Sheng 2true in vitro and in vivo. For in vitro study, NGO showed a good photothermal conversion effect, increasing temperature under laser irradiation to destroy tumor cells. In addition, NGO could effectively stimulate the production of IL-6 and TNFα by macrophages and enhance the immune response of macrophages to laser-treated tumor cells. For in vivo study, two tumors were inoculated on both sides of the back of mice, serving as the local primary tumor and surrogate distal metastatic tumor. The results showed that the treatment of NGO combined with laser could effectively ablate the treated primary tumor, and inhibit the growth of untreated distal tumor. It suggested that the treatment of NGO combined with laser therapy could stimulate the anti-tumor immune response of the body to attack distal metastases.]]> 2017/12/19 0:00:00 LI Yong, ZHOU Fei-Fan and CHEN Wei 1true