2014/3/25 0:00:00 CHEN Chang 11true 2014/3/24 0:00:00 LIU Jun-Ping 10true 2014/3/24 0:00:00 YUAN Ting-Ting,YANG Ji-Ping,GUAN Di,DING Zhi-Chao and LIU Guang-Hui 9true 2014/3/24 0:00:00 AN Rui,YI Wei-Wei and JU Zhen-Yu 8true 2014/3/25 0:00:00 ZHU Yu-Shan,Liu Jin-hua,LU Tie-Yuan and CHEN Quan 7true 2014/3/25 0:00:00 HE Jie-Yu and LIU Feng 6true 2014/3/24 0:00:00 CHENG Qian,YUAN Fu-Wen and TONG Tan-Jun 5true Caenorhabditis elegans (C. elegans), Drosophila, mice and human by targeting many aging related pathways. In this review, we summarize the recent literatures on various regulatory roles of miRNAs during aging. We introduce the pathways that function in the aging process and highlight how certain miRNAs regulate aging and aging related diseases through these pathways at the levels of organism lifespan, tissue aging and cellular senescence. Finally, we discuss future perspectives on the study of the mechanisms by which miRNAs modulate aging processes.]]> 2014/3/25 0:00:00 WU Gang,WANG Dan,HUANG Yi and HAN Jing-Dong 4true 2014/3/25 0:00:00 HU Ming-Xi,ZHANG Xu and CHEN Chang 3true 2014/3/24 0:00:00 JIANG Ping and LI Jian 2true C. elegans, which is a great system for biology research because of the ease of genetic analysis and the conservation with higher species. Here we review the progress in aging research using C. elegans as a model. We focus on the highly conserved insulin/insulin-like growth factor 1 signaling (IIS) and target of rapamycin (TOR) pathway, as well as prospects for future studies.]]> 2014/3/25 0:00:00 CHEN Di 1true