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<title cf:type="text"><![CDATA[Progress in Biochemistry and Biophysics -->Interpretation of the Nobel Prize in Physiology or Medicine 2021]]></title>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Discoveries of Receptors for Temperature and Touch]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20210323]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The 2021 Nobel Prize in Physiology or Medicine is awarded to American physiologist David Julius and molecular biologist Ardem Patapoutian for their groundbreaking discoveries of receptors for temperature and touch. The ability to perceive external stimuli, such as hot and cold sensation and mechanical pressure, is crucial to our adaptation to the ever-changing environment, protecting us from harm. Prior to the discoveries of this year’s laureates, how temperature and mechanical stimuli are perceived and converted into electrical pulses was unknown. Unveiling of the temperature receptor TRPV1 and the touch receptors PIEZOs led to a thorough understanding of this process, also revealing more members of the TRP receptor family and PIEZO receptor family, furthermore encouraging scientists to research on its mechanisms and functions, pointing towards innovative treatment methods for tackling pain at the root. This article summarizes the discovery process, structure and mechanisms of these two receptors and also introduces illnesses caused by receptor mutations, shining light on their role as potential targets for drug development.]]></description>
<pubDate>2021/12/23 13:40:38</pubDate>
<category><![CDATA[Interpretation of the Nobel Prize in Physiology or Medicine 2021]]></category>
<author><![CDATA[LIU Ling-Yun]]></author>
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<atom:name>LIU Ling-Yun</atom:name>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Temperature Sensor TRPV1 Regulates Pain]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20210303]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The 2021 Nobel Prize in physiology or medicine was awarded to David Julius and Ardem Patapoutian, based on the outstanding contributions in temperature receptors TRPV1 and tactile receptors PIEZO1/PIEZO2, respectively. They elucidated the mechanisms underlying how the human nervous system senses cold/heat and mechanical stimulation, which contributes to the development of drugs for long-term pain. This article reviews David Julius’ pioneering work on TRPV1 which can be activated by capsaicin, heat (>43℃), H<sup>+</sup> (pH<6.0), and the critical roles of TRPV1 participating in cancer pain, chronic inflammatory pain, neuropathic pain, and visceral pain by inducing peripheral and/or central sensitization.]]></description>
<pubDate>2021/12/23 13:40:39</pubDate>
<category><![CDATA[Interpretation of the Nobel Prize in Physiology or Medicine 2021]]></category>
<author><![CDATA[WU Yi-Qing,TONG Zhi-Qian and WAN You]]></author>
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<atom:name>WU Yi-Qing,TONG Zhi-Qian and WAN You</atom:name>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Discovery of Touch Receptor NOMPC and Hearing Receptor TMC]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20210370]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Human have several senses, including vision, touch, hearing, taste, smell and taste, as well as temperature and pain. How organisms perceive the physical world has always attracted people to explore. Although new breakthroughs have been made in the discovery and research of different sensory receptors, the underlying molecular and cellular mechanisms of these sensation remain elusive. The 2021 Nobel Prize in physiology or medicine was awarded to David Julius and Ardem Patapoutian for their profound contributions to the discovery of temperature sensing and tactile receptors. For hearing research, although it won the Nobel Prize as early as 1961, the research on hearing receptors is still insufficient. This article review focuses on the discovery and research process of touch and hearing receptor NOMPC in invertebrate and hearing receptor TMC in mammalian. And this review also provides suggestions for the development of sensory perception in the future.]]></description>
<pubDate>2021/12/23 13:40:42</pubDate>
<category><![CDATA[Interpretation of the Nobel Prize in Physiology or Medicine 2021]]></category>
<author><![CDATA[PAN Xue-Qi and YAN Zhi-Qiang]]></author>
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<atom:name>PAN Xue-Qi and YAN Zhi-Qiang</atom:name>
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