etc., thus affecting various biological processes. Based on recent research progress on long noncoding RNAs, this review aims to summarize their origin and evolution, novel kinds of long noncoding RNAs, typical functional mechanisms of long noncoding RNAs, and their roles in development and reprogramming. We also tried to update studies on epigenetic regulation of long noncoding RNAs as well as their roles in cancer research, and some closely related modern technologies for long noncoding RNAs. Systematic screen of long noncoding RNAs and the elaboration of their functional mechanisms will play critical roles in the progress of modern life sciences.]]> 2014/10/23 0:00:00 CHEN Xiao-Min,ZHANG Dong-Dong,LUO Jian-Jun and CHEN Run-Sheng 10true 2014/10/23 0:00:00 SUN Cui-Wei,WANG Xian-Hua and CHENG He-Ping 9true 2014/10/23 0:00:00 ZHANG Ke and DENG Hong-Kui 8true 2014/10/23 0:00:00 GAO Fu and SHI Yi 7true Progress in Biochemistry and Biophysics, I would like to sing my heart song, "Ode to the Brain". The Human Brain is like the long river of history. It from ancient to today, and will from today to the future. Human brain is the most fine, most complex, most beautiful and the most successful organ created by the long natural selection process. It is the greatest miracle of intellectual evolution. It is the source of human intelligence, is the human spiritual home. The wisdoms of the human brain created and promote the formation of the social inheritance of human knowledge and civilization. Until now, we still don't know how the human brain works. We believe that the brain functional connectomics may be a key to crack the secret of the brain.]]> 2014/10/24 0:00:00 GUO Ai-Ke 6true 2014/10/24 0:00:00 CHANG Jiang,WEI Li-Xuan,WU Chen,YU Dian-Ke,TAN Wen and LIN Dong-Xin 5true 2014/10/24 0:00:00 ZHANG Li and SHAO Feng 4true 2014/10/24 0:00:00 CHAI Ji-Jie and SHI Yi-Gong 3true 2014/10/24 0:00:00 YANG Na and XU Rui-Ming 2true 2014/10/24 0:00:00 SONG Nan,LI Tao and ZHANG Xue-Min 1true