本专题主要对自噬与一些相关疾病关系的现状和发展进行了评述，并对自噬研究方法学和基本机制也进行了综述，同时报道了在果蝇脊髓小脑变性3型动物模型中开展的关于自噬与Sir2发挥神经保护作用相关性的研究，反映了目前自噬研究的一个侧面。马泰等主要综述了目前自噬研究的技术和方法进展，评价了自噬的评估指标和这些自噬方法学的应用，提供了一个自噬方法学上的基础交流。吴葩等介绍了PI3K复合物中各组分蛋白与细胞自噬的关系，详细阐述了该通路在细胞自噬调节中的最新研究进展，为这一信号通路研究提供了信息。何云凌等很好地总结了低氧环境诱导线粒体自噬发生的相关分子机制，对参与调节线粒体自噬的重要蛋白进行了系统的描述，为目前人们普遍关注的线粒体自噬与疾病的关系提供了前沿资料。谢凤等对心脏疾病状态下细胞自噬的发生、发展及其对心脏疾病的影响进行了详细的论述，有助于研究者从自噬的角度来探讨心脏疾病的发生发展及其机制。林小龙等围绕当前热点问题对自噬与血管内皮细胞的关系作了描述，介绍了血管内皮细胞在各种药物刺激以及相关蛋白质过表达情况下对于自噬的反应以及所引起的下游应答，探讨了自噬与血管疾病发病的相互关系。向波等介绍了细胞自噬与肿瘤的发生发展的关系，描述了炎症-自噬-肿瘤的相关性以及自噬可能的抑瘤机制。曾爱源等利用果蝇的遗传性脊髓小脑变性3 型模型，研究了Sir2在自噬存在情况下对转基因果蝇的神经保护作用，并发现在自噬抑制后Sir2的保护作用明显减弱，揭示了Sir2通过自噬保护神经元、减缓神经变性蛋白损伤的作用机制。
本刊欢迎和期待更多、更好的有关自噬研究的来稿，以更广泛和深入地促进我国自噬研究领域的发展和学术交流。]]> 2012/3/21 0:00:00 WANG Guang-Hui 8true in vitro or in vivo models has also been considered as important part of autophagy analysis. Any method currently used alone may not been as evidence of autophagy. More careful attention should be paid on results of any assays of autophagy, especially DO NOT interpret "increase or decrease of autophosome" (also "up- or down-expression of autophagy-related proteins") as "enhancement or attenuation of autophagic function".]]> 2012/3/21 0:00:00 MA Tai,SUN Guo-Ping and LI Jia-Bin 7true 2011/12/20 0:00:00 WU Pa and XU Cai-Min 6true 2011/11/23 0:00:00 HE Yun-Ling,WU Li-Ying,ZHU Ling-Ling and FAN Ming 5true 2012/3/21 0:00:00 XIE Feng,LIU Wei and CHEN Lin-Xi 4true 2012/3/21 0:00:00 LIN Xiao-Long,MA Xiao-Feng,LI Shuang,ZHAO Yue and WANG Zuo 3true 2012/3/21 0:00:00 XIANG Bo,YI Mei,LI Xiao-Ling and LI Gui-Yuan 2true Drosophila models were constructed by using the promoter GMR-GAL4 and Nrv2-GAL4 which drive target selective gene expression in cells of the developing eyes and motor neurons, respectively. Then, Sir2 protein was overexpressed in SCA3/MJD transgenic Drosophila models by genetic methods with or without in a background of RNAi knockdown of Atg7. Overexpression of endogenous Drosophila Sir2 not only notably suppresses the neurotoxicity of MJDtr-Q78 protein, but also significantly improves the movement ability of flies. Moreover, RNAi knockdown of Atg7 significantly Sir2's protection against SCA3/MJD Drosophila. We confirmed that overexpression of Sir2 could protect SCA3/MJD Drosophila models, and the protection role of Sir2 on SCA3/MJD Drosophila models is autophagy-dependent.]]> 2011/9/27 0:00:00 ZENG Ai-Yuan,ZHU Jing-Lei,HONG Kang-Kang,ZHANG Zhuo-Hua,DUAN Ran-Hui,SUN Li,LIU Cheng-Wei,WEI Xiao-Li,WEI Li-Li,CHEN Mei-Ling,LIN Xiao-Hui,CHEN Wei and lI Qing-Hua 1true