本刊在这期中特意选择了3篇文章组成了一个小专题来介绍与探讨siRNA的输送问题。梁伟等应邀撰写了题为《siRNA脂质纳米输送载体的研究进展》的综述，介绍了siRNA输送载体的基本要求，特别是脂质纳米载体(lipid-based siRNA delivering systems)的设计和构筑原则，以及这类载体的研发现状和应用前景；张洪杰等结合自身的研发工作撰写了《细胞穿透肽及其结构改造在siRNA传递中的应用》一文，从发现、毒副作用、传递机制、结构修饰与传递功能改进等几个方面，系统评述了细胞穿透肽(cell penetrating peptides)在siRNA传递方面研究与应用的进展；张兴梅等在《适配子介导的siRNA转运》一文中重点介绍了基于适配子(aptamer)的siRNA转运系统的转运机制、近期研究进展和应用前景。3篇文章各有侧重，反映了当前siRNA转运研究中几个比较活跃的领域的研究进展，希望能对广大读者有所帮助。]]> 2012/5/25 0:00:00 CHEN Run-Sheng 4true 2012/5/25 0:00:00 DONG Wen-Juan,ZHOU Yin-Jian and LIANG Wei 3true et al., Mol Ther (2011)19, 362-371). CPPs are short amphipathic and cationic peptides that are rapidly internalized across cell membranes. They can be used to deliver molecular cargos, such as imaging agents (fluorescent dyes and quantum dots), drugs, liposomes, peptide/protein, oligonucleotide/DNA/RNA, nanoparticles and bacteriophage into cells. The mechanism of cellular uptake and subsequent processing still remains controversial. It is now clear that CPP can mediate intracellular delivery via both endocytic and non-endocytic pathways. In this review, we discuss potential functions of CPPs, especially in structure modified CPPs for small RNA delivery in vitro and in vivo, highlighting their powerful promise for clinical efficacy.]]> 2012/3/19 0:00:00 ZHANG Hong-Jie and YIN James-Qin-wei 2true 2012/4/23 0:00:00 TAN Yan and ZHANG Xing-Mei 1true