2022/4/22 0:00:00 Song Li-Juan,YANG Rong-Fang and ZHANG Shu-Li 15true 2022/4/22 0:00:00 JI Juan-Juan 14true Objective With the rapid development of the bio-industry, more and more biological enterprises, mainly biomedical enterprises, have emerged. How to promote the output efficiency of biological enterprises is the most concern of the government and enterprises themselves.Methods This paper constructs a DEA model to evaluate the input-output efficiency of 370 listed companies in China’s biological industry.Results The research results show that the average comprehensive technical efficiency of listed companies in China"s biological industry is 0.596, and there is still much room for improvement.Conclusion The main factor restricting the overall technical efficiency of listed companies in China’s biological industry is pure technical efficiency. Large-scale listed biological companies should optimize investment and reduce redundancy, while smaller-scale listed biological companies need to expand their scale.]]> 2022/2/21 0:00:00 DING Jun-Qi,BAI Jing-Yu and LIN Xiao-Feng 13true 2022/12/20 0:00:00 CONG Chao,ZHAO Wan-Qiu,LIU Jian-Kun and HUANG Fen 12true 2022/12/20 0:00:00 JI Teng-Qi and ZHANG Ji 11true et al. (2023) have reported that individuals with high trait anxiety exhibit attentional deficits characterized by reduced inhibition of distractors and delayed attentional selection of targets, indicating impaired top-down attentional control. This commentary underscores their significant contributions to the cognitive theory of anxiety. Based on their findings, we propose a novel training approach called attentional inhibition training (AIT), aimed at improving top-down attentional control to alleviate symptoms of anxiety. Furthermore, we explore the potential application of non-invasive transcranial magnetic stimulation (TMS) for rapidly enhancing attentional control function.]]> 2024/10/30 20:34:41 MA Hao-Yun,LIANG Jian-Hui and LIU Dong-Qiang 10true Human Brain Mapping, shows a new function of the subcortical pathway involved in the fast processing of non-emotional object perception. Rapid object processing is a critical function of visual system. Topological perception theory proposes that the initial perception of objects begins with the extraction of topological property (TP). However, the mechanism of rapid TP processing remains unclear. The researchers investigated the subcortical mechanism of TP processing with transcranial magnetic stimulation (TMS). They find that a subcortical magnocellular pathway is responsible for the early processing of TP, and this subcortical processing of TP accelerates object recognition. Based on their findings, we propose a novel training approach called subcortical magnocellular pathway training (SMPT), aimed at improving the efficiency of the subcortical M pathway to restore visual and attentional functions in disorders associated with subcortical pathway dysfunction.]]> 2025/5/19 14:18:10 MA Hao-Yun,WEI Yu-Yin and HU Li-Ping 9true Cell the first structural elucidation of how microtubules regulate immune responses by “sequestering and releasing” the guanine nucleotide exchange factor GEF-H1 protein. This work addresses a central question in microtubule-mediated signal transduction, provides a conceptual and methodological framework for basic research, and offers new targets and strategies for cancer immunotherapy and targeted drug development.]]> 2026/5/30 21:52:46 REN Jin-Qi 8true 2026/5/14 11:42:00 TONG Ming-Qiong,YIN Yue-Wen,SHI Zhi-Hong and CAO Zan-Xia 7true Cell has uncovered a novel functional dimension of DCs. Beyond their classical roles in antigen presentation and T cell priming, DCs dynamically regulate the spatiotemporal organization of innate and adaptive immune responses within lymph nodes. During early type I immune responses, tissue-resident DC2s recruit innate immune cells and promote their trafficking, effectively limiting pathogen spread; however, this comes at the cost of disrupting lymph node architecture and suppressing the initiation of adaptive immunity. Following effective pathogen restraint, DCs shift their role to mediate the removal of apoptotic neutrophils and facilitate the restoration of lymph node structure, thereby reinstating adaptive immunity. These findings suggest that a deeper understanding of subset-specific regulatory networks of DCs in various immune contexts may enhance the precision and efficacy of DC-targeted immunotherapies.]]> 2026/5/25 11:00:44 YANG Shao-Jun and ZHANG Xu-Yuan 6true et al. (2025) based on low-input proteomic approaches systematically charted protein dynamics from oocytes to blastocysts in both mice and humans, further interrogating molecular signatures of developmentally compromised human embryos at the single-embryo level. This work not only substantially expands proteome coverage during early development, but also reveals a pervasive uncoupling between transcriptional activation, translational initiation, and protein accumulation. These findings provide new perspectives on the relationship between zygotic genome activation (ZGA) and lineage specification. This paper discussed the central role of low-input proteomics in this study, highlighted its implications for reshaping current paradigms of early embryonic development, and considered its potential applications across broader areas of biomedical research.]]> 2026/3/17 15:02:15 CHEN Hong-Yu 5true + modification), but also highlights their remarkable chemical plasticity and evolutionary innovative capacity. It provides a new perspective for understanding the origin and diversity of immune signaling.]]> 2026/2/10 17:19:05 LU Qiang and CHENG Rui 4true 2026/3/4 14:24:32 WANG Yi,CHEN Zhe,LI Xin and CHEN Lin-Xi 3true Emerging Microbes & Infections demonstrated that the RAD6A-RAD18 ubiquitination complex plays a unique and pivotal role in the nuclear-cytoplasmic trafficking of the HNV M protein and the process of viral budding. Furthermore, this study revealed that treating cells with TZ9 (a RAD6 inhibitor) or RAD18 RING domain-binding peptides markedly impaired the ubiquitination level of HNV M protein, resulting in its nuclear retention and subsequent impairment of viral budding and replication. These findings lay a theoretical foundation for the development of novel antiviral drugs and specific antiviral therapies targeting HNV infections, and provide valuable references for investigating the biological functions of M protein’s ubiquitination as well as the replication and pathogenic mechanisms of other paramyxoviruses.]]> 2026/2/2 11:45:41 DUAN Zhi-Qiang 2true Brain Stimulation by Chen et al. addressed these challenges by combining a high-dose intermittent theta-burst stimulation (iTBS) protocol with concurrent transcranial magnetic stimulation-electroencephalography (TMS-EEG). This commentary provides an in-depth analysis of their findings, highlighting the restoration of cerebello-cortical inhibition (CBI) as a key therapeutic mechanism. Furthermore, we discuss the broader implications of this work, proposing that future translational research should integrate accelerated iTBS (aiTBS) paradigms, cortical response measurements (CRM), and individualized neuro-navigation to establish a new era of precision neuromodulation for ataxia.]]> 2026/2/2 8:46:54 HAN Ya-Zhen,ZHOU Jie,CHEN Yu-Chao,GAO Zhong-Ming and CHE Xian-Wei 1true