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<title cf:type="text"><![CDATA[Progress in Biochemistry and Biophysics -->Letter to Editor]]></title>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[GRP75 of CHO Cells Responds to Ribosylation]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20140314]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[GRP75 of CHO Cells Responds to Ribosylation]]></description>
<pubDate>2014/11/24 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[LU Yang and HE Rong-qiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LU Yang and HE Rong-qiao</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20140314]]></guid><cfi:id>10</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemoresistance to CDDP Induces EMT Through Activation of RAC1 in SKOV3 Human Ovarian Cancer Cells]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The incidence rate of epithelial ovarian cancers ranks third among female reproductive system cancers, and its mortality rate stands first among the list of gynecologic tumors. The standard mode of treatment is cytoreductive surgery (debulking) plus the administration of platinum-based chemotherapy drugs. About 70% of advanced patients who receive standard treatments can achieve clinical remission. However, a certain percentage of patients with clinical remission will still experience tumor recurrence, metastasis, and drug resistance.  this study focuses on the occurrence process of EMT in SKOV3 cells, which is mediated by RAC1 activation, as well as the relationship between the process of cell sensitivity and cisplatin (CDDP), and the ability of invasion and metastasis.]]></description>
<pubDate>2015/2/6 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[ZENG Yong and XIA Kun]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ZENG Yong and XIA Kun</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150002]]></guid><cfi:id>9</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Effects of Protein Corona on Intracellular Uptake and Cytotoxicity of PM<sub>1</sub>]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160109]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Effects of Protein Corona on Intracellular Uptake and Cytotoxicity of PM<sub>1</sub>]]></description>
<pubDate>2016/6/22 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[ZHANG Lu-Yao, ZHANG Wei, DING Wen-Jun and ZHANG Fang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ZHANG Lu-Yao, ZHANG Wei, DING Wen-Jun and ZHANG Fang</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160109]]></guid><cfi:id>8</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Na<sup>+</sup> Binding and pH-Dependent Transport in <i>Nonlabens dokdonensis</i> Rhodopsin 2]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170164]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Recently discovered light-driven Na  pumps are novel optogenetic tools. Activated by light, they actively transport Na  outward across cell membrane. However, the mechanism of Na  transport remains elusive. Visible absorption spectra, fluorescence spectra and ITC results of NdR2, a light-driven Na  pump, indicated that Na  may not bind to NdR2 in the ground state. Moreover, Na  transport kinetics and functional assay suggested that Na  transport might be altered at acidic pH. This pH-dependent transport of Na  may shed light on and the mechanism of Na  transport in NaRs.]]></description>
<pubDate>2017/7/18 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[ZHAO Hong-Shen and CHEN De-Liang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ZHAO Hong-Shen and CHEN De-Liang</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170164]]></guid><cfi:id>7</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Study on The Relationship of Laser Power Density and Localization Precision in PALM Imaging]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170153]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[PALM imaging based on single molecule localization has developed rapidly in the past decades.Using PALM, the resolution of microscope has been increased to 2-25 nm. In this study, we find that there is a close relationship between the laser power density and the localization precision in PALM imaging. To explore this relationship ,we tested the most commonly used fluorescent proteins (FPs), including photoactivatable, photoconvertable, and photoswitchable FPs in PALM imaging. The results show that with the increase of the laser power density, the photon yield of most FPs firstly increased and then became saturated, and the background noise increased almost linearly. The analysis shows that with the increasing laser power density, the localization error first decreased, and then increased. Therefore, it is very important to select the appropriate laser power density in PALM imaging. How to improving the resolution of PALM imaging has been a hot research topic. The results in this study can guide researchers to select appropriate laser power density in PALM imaging to obtain images with high resolution.]]></description>
<pubDate>2017/6/20 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[FAN Chun-Yan, LI Yuan-Yuan, GU Lu-Sheng, LI Wei-Xing, XU Xiao-Jun, ZHANG Shu-Wen, WANG Lei, CHEN Yan, XUE Yan-Hong and JI Wei]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>FAN Chun-Yan, LI Yuan-Yuan, GU Lu-Sheng, LI Wei-Xing, XU Xiao-Jun, ZHANG Shu-Wen, WANG Lei, CHEN Yan, XUE Yan-Hong and JI Wei</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170153]]></guid><cfi:id>6</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[PLK1 is a Novel Partner for DNA Endonuclease CtIP]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170051]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[CtIP is one of the key proteins in DNA double strand breaks repair whereby promoting the end resection. It is a known tumor suppressor and interacts with a number of proteins involved in carcinogenesis such as BRCA1, Rb, etc. To better understand the molecular networks of CtIP, CtIP interaction proteins were predicted with online tool PrePPI and PLK1 was found as the novel CtIP interaction protein which plays an essential role in mitosis and also cancer progression. We further validated the novel interaction by immunoprecipitation method. PLK1 showed strong interaction with CtIP. Moreover, Frodock 2.0 tools for docking protein interactions between CtIP and PLK1 was employed. Finally, the immuoprecipitation assay and immunofluorescence staining results showed the interaction between these two proteins are related to DNA damage. Based on these results, we proposed that the CtIP-PLK1 interaction may play important roles in DNA damage response as well as other biological processes.]]></description>
<pubDate>2017/4/24 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[XIE Yu, JIN Feng, GUO Zong-Pei, SONG Zhi-Quan, GAO Shan-Shan, LIU Xiao-Dan, MA Teng and ZHOU Ping-Kun]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>XIE Yu, JIN Feng, GUO Zong-Pei, SONG Zhi-Quan, GAO Shan-Shan, LIU Xiao-Dan, MA Teng and ZHOU Ping-Kun</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170051]]></guid><cfi:id>5</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[The Effects and Mechanisms of Syntaxin-1 on The Differentiation of Murine Neuroblastoma]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170331]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Syntaxin is a multi-domain protein that is specifically distributed in the presynaptic membrane of neuron. It is one of the key proteins in membrane fusion. However, the roles of Syntaxin in nerve cell differentiation remain unclear. In this study, wild type and different mutats of Syntaxin were overexpressed in the mouse neuroblastoma cells (N2a). Parameters such as differentiation rate of the cell, number of branches and total length of the neurite were analyzed to determine the effects of Syntaxin in neuronal differentiation. Our results suggested the Habc domain of Syntaxin was the main functional structure in differentiation process. The number of branches and total length of the neurite, but not the differential rate, were affected by Syntaxin overexpression.]]></description>
<pubDate>2017/11/20 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[LIU Meng-Xue, LIN Yin, RONG Yi and YANG Xiao-Fei]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LIU Meng-Xue, LIN Yin, RONG Yi and YANG Xiao-Fei</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170331]]></guid><cfi:id>4</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Human Nucleosome Assembly Protein 1-Like 5 (NAP1L5) Promotes The Proliferation of 293T Cells]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20180006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Human NAP1L5 is a member of the nucleosome assembly protein (NAP-1) family, until now its function has been completely unknown. In liver cancer, Nap1l5 was suggested as a tumor suppressor gene, and might inhibit cell proliferation. However, it’s reported that many NAP-1 family members promote cell cycle progression. Whether human NAP1L5 promotes or inhibits cell proliferation has been undetermined yet. Here, we found that the proliferation of 293T cells was promoted by Nap1l5 overexpression, and inhibited by knockdown of its expression. Cell cycle analysis showed that compared with control groups, Nap1l5-overexpressed cells had higher percentage of cells in G2-phase, and lower percentage in G1-phase; instead, knockdown of Nap1l5 expression increased the percentage of cells in G1-phase, and decreased the percentage in G2-phase. Our study demonstrated that human NAP1L5 could promote cell proliferation as well as accelerate cell cycle progression, and suggested that the original postulation of Nap1l5 as a tumor suppressor gene was incorrect.]]></description>
<pubDate>2018/4/19 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[LI Min, ZHANG Hai-Tao, LI Zong-Hong, HOU Jun-Jie and XU Xiao-Lan]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LI Min, ZHANG Hai-Tao, LI Zong-Hong, HOU Jun-Jie and XU Xiao-Lan</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20180006]]></guid><cfi:id>3</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Free Fatty Acids Induce Pyroptosis in Pancreatic β-Cells]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170406]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[One of the feature of the pathogenesis of type 2 diabetes is lipotoxicity-induced reduction in pancreatic β-cell mass. To study the mechanism by which free fatty acids cause β-cell death, we studied the contribution of different cell death pathways induced by palmitate in the β-cell line INS1. In addition to previously reported apoptosis, we propose pyroptosis as a novel pathway that partially contributes to the pancreatic β-cell death induced by free fatty acids using the real-time lapse image. We provide evidence that the mechanism of pyroptosis could involve DFNA5.]]></description>
<pubDate>2018/3/21 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[LI Zong-Hong, XUE Miao-Miao, LIU Hong-Yang, HOU Jun-Jie, XU Tao and ZHOU Yi-Fa]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LI Zong-Hong, XUE Miao-Miao, LIU Hong-Yang, HOU Jun-Jie, XU Tao and ZHOU Yi-Fa</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170406]]></guid><cfi:id>2</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Visualization of Mitochondrial Membrane Dynamics in Primary Cultured Neurons by Cryo-electron Tomography]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20210302]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The fission and fusion of mitochondria is the main way of dynamic changes of mitochondrial membrane, and it is also an important means to maintain the normal function of mitochondria. The mechanism of mitochondrial fission used to be based on fluorescent-labeled optical microscopy imaging. Due to the limitation of resolution, it is not possible to directly observe the ultrastructural characteristics of the mitochondrial fission. Cryo-electron tomography (cryo-ET) obtains more realistic structural information by maintaining the physiological state of the sample as much as possible. In this article, we use cryo-ET to study the membrane dynamic of mitochondrial fission in primary hippocampal neurons. By imaging the spontaneous mitochondrial fission, we found that both central and peripheral mitochondrial fission have contact with the endoplasmic reticulum (ER). It is worth noting that we have also found that some mitochondria will separate the outer mitochondrial membrane from the inner membrane, forming a "matrix-free" area. All these may show a way of mitochondrial quality control.]]></description>
<pubDate>2021/11/23 0:00:00</pubDate>
<category><![CDATA[Letter to Editor]]></category>
<author><![CDATA[WANG Pei,TIAN Bu-Yun,FENG Feng-Ping,LUAN Hui-Qin,XU Xiao-Jun,JI Wei and XUE Yan-Hong]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>WANG Pei,TIAN Bu-Yun,FENG Feng-Ping,LUAN Hui-Qin,XU Xiao-Jun,JI Wei and XUE Yan-Hong</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20210302]]></guid><cfi:id>1</cfi:id><cfi:read>true</cfi:read></item>
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