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<title cf:type="text"><![CDATA[Progress in Biochemistry and Biophysics -->News and Views]]></title>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Long non-coding RNA AFAP1-AS1 promotes cancer invasion and metastasis]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150161]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Long non-coding RNA AFAP1-AS1 promotes cancer invasion and metastasis]]></description>
<pubDate>2015/12/18 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[ZENG Zhao-Yang, BO Hao, GONG Zhao-Jian, LI Xia-Yu, LIAN Yu, JING Yi-Zhou, TANG Yan-Yan, CHEN Pan, LIAO Qian-Jin, LI Xiao-Ling, XIONG Wei and LI Gui-Yuan]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ZENG Zhao-Yang, BO Hao, GONG Zhao-Jian, LI Xia-Yu, LIAN Yu, JING Yi-Zhou, TANG Yan-Yan, CHEN Pan, LIAO Qian-Jin, LI Xiao-Ling, XIONG Wei and LI Gui-Yuan</atom:name>
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<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150161]]></guid><cfi:id>14</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Making concerted efforts to get a scientific break-through: A glance back at structure analysis of Artemisinin]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150320]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Making concerted efforts to get a scientific break-through: A glance back at structure analysis of Artemisinin]]></description>
<pubDate>2015/10/21 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[DONG Yi-Cheng and HE Rong-Qiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>DONG Yi-Cheng and HE Rong-Qiao</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150320]]></guid><cfi:id>13</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[The DNA repair researchers were awarded by Nobel Commitee and Lasker Foundation in the same year]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150321]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The DNA repair researchers were awarded by Nobel Commitee and Lasker Foundation in the same year]]></description>
<pubDate>2015/10/21 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[HANG Hai-Ying]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HANG Hai-Ying</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150321]]></guid><cfi:id>12</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Consciousness and anesthesia]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150304]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The definition of consciousness can be described as "a brain basic function that an individual realizes oneself in a real world (environment)." This is to say, consciousness works for human to perceive the reality of oneself and the environment under wakefulness. The perception of the reality is a brain fundamental function for attention, learning, cognition and thinking, etc. So far, many scientific laboratories study human consciousness related with anesthesia because they attempt to reveal how consciousness works when brain reboots awareness. Recently, Solovey and colleagues (<i>J Neurosci</i>, 2015, <b>35</b>(30): 10866) found that different anesthetics induce different patterns of brain activity. Loss of consciousness is universally and reliably associated with stabilization of cortical dynamics regardless of the specific activity characteristics.To give an analogy, their analyses suggest that loss of consciousness is akin to depressing the damper pedal on the piano, which makes the sounds dissipate quicker regardless of the specific melody being played. Here is a suggestion that the consciousness under the basic metabolism should be observed when a person just awake from asleep state, because s/he just realizes herself or himself in a real world, without disturbance from those of drugs for anesthesia of brain.]]></description>
<pubDate>2015/10/21 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[HE Rong-Qiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HE Rong-Qiao</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20150304]]></guid><cfi:id>11</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Perceiving Beauteousness with Our Peripheral Vision]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160187]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Perceiving Beauteousness with Our Peripheral Vision]]></description>
<pubDate>2016/6/22 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[HE Rong-Ding and HE Rong-Qiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HE Rong-Ding and HE Rong-Qiao</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160187]]></guid><cfi:id>10</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Abnormal lysosome, Formaldehyde Dysmetabolism and age-related cognitive impairment]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160364]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Abnormal lysosome, Formaldehyde Dysmetabolism and age-related cognitive impairment]]></description>
<pubDate>2016/12/22 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[HE Rong-Qiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HE Rong-Qiao</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160364]]></guid><cfi:id>9</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Milk: new transmission route of hepatitis e virus]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160221]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Milk: new transmission route of hepatitis e virus]]></description>
<pubDate>2016/10/24 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[LI Yun-Long, PENG Fu-Chun, YU Wen-Hai, HUA Xiu-Guo, JING Shen-Rong and HUANG Fen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LI Yun-Long, PENG Fu-Chun, YU Wen-Hai, HUA Xiu-Guo, JING Shen-Rong and HUANG Fen</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160221]]></guid><cfi:id>8</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[ABCA1 structure and cholesterol efflux]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170264]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[ATP binding cassette transporter A1 (ABCA1) is a transmembrane protein that regulates intracellular cholesterol efflux and is closely related to the development of atherosclerosis (AS). But its structure and molecular mechanisms are still unclear. Recently an issue published on Cell (2017,169:1228-1239) by researchers from Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, China reported the cryo-EM structure of human ABCA1 and suggested a plausible ‘‘lateral access’’ mechanisms for ABCA1-mediated lipid export.]]></description>
<pubDate>2017/9/21 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[WANG Si-Qi, ZHANG Min, CHEN Ling-Yan and TANG Chao-Ke]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>WANG Si-Qi, ZHANG Min, CHEN Ling-Yan and TANG Chao-Ke</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170264]]></guid><cfi:id>7</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[LINCS：a big data project of cell response for translational medicine]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160372]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Maturing low-cost acquisition technology of multi-omics data, e.g. transcriptome and proteome data, continues to generate extensive amounts of cellular response data in numerous physiological and pathological condition. Researchers can use these data to explore the mechanism of biological processes, infer the generation and development of diseases, and discover the targets of drugs. In 2010, the National Institutes of Health (NIH) launched a project named Library of Integrated Network-based Cellular Signatures (LINCS). The project established an integrated network-based cellular response database by measuring the change of gene expression and other levels of cellular response after a series of perturbations, illustrated that how cell reacts under multiple genetic and environmental stresses, and connected basic medical research and clinical therapy to promote the rapid development of translational medicine. Here we review the origin, significance, experimental technology, quality control, data content and analysis tools of the LINCS project. We also summarize the applied research of the LINCS project in the aspects of gene regulation, disease generation, and adverse drug reactions.]]></description>
<pubDate>2017/11/20 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[HUANG Xin, HE Song, LIU Yang, BAI Hui and BO Xiao-Chen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HUANG Xin, HE Song, LIU Yang, BAI Hui and BO Xiao-Chen</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20160372]]></guid><cfi:id>6</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Local details first：sensory perception in autism]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170398]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Local details first：sensory perception in autism]]></description>
<pubDate>2017/11/20 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[HE Rong-qiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HE Rong-qiao</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20170398]]></guid><cfi:id>5</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Immunotherapy targeted to immune checkpoint: a revolutionary breakthrough in cancer therapy]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20180264]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The 2018 Nobel Prize in Physiology or Medicine was awarded jointly to James P. Allison and Tasuku Honjo for their contributions to cancer therapy by inhibition of negative immune regulation. This discovery sheds new light on immunotherapy. In this paper we reviewed the research on CTLA-4 and PD-1, two well-studied immune checkpoints. We also investigated the drug development and clinical use which are targeted to immune checkpoint, as well as the development of immunotherapy in China. Meanwhile, we discussed the limitations in immunotherapy at present and the solutions to solve the problem of adverse effects existed in immunotherapy. China has made great progress in the research of immunotherapy because of the young talents coming back to China and the excellent research platforms as well as the great investment in the field of immunotherapy in recent years. There is no doubt that the immune checkpoint inhibitors developed by China will be accepted globally and China will make great contributions to the cancer therapy in the near future.]]></description>
<pubDate>2018/11/19 0:00:00</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[JIANG Xian-Jie, WANG Jie, DENG Xiang-Ying, LI Xiao-Ling, LI Xia-Yu, ZENG Zhao-Yang, XIONG Wei, LI Gui-Yuan, XIONG Fang and GUO Can]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>JIANG Xian-Jie, WANG Jie, DENG Xiang-Ying, LI Xiao-Ling, LI Xia-Yu, ZENG Zhao-Yang, XIONG Wei, LI Gui-Yuan, XIONG Fang and GUO Can</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20180264]]></guid><cfi:id>4</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Intrinsic Disorder Regulates Activation of Ash1/Ash1L Histone Methyltransferase]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20190109]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[组蛋白甲基化修饰与基因的转录调控密切相关，其中果蝇的Ash1以及哺乳动物的同源蛋白Ash1L是催化组蛋白H3上36位赖氨酸进行单甲基化和双甲基化的甲基转移酶. 由于存在一个自抑制环区阻挡了底物的结合位点，Ash1/Ash1L本身的组蛋白甲基转移酶活性是很低的. 但与Mrg15结合后，Ash1/Ash1L从原来的自抑制态转变为活化态. 最近，Ash1L与Mrg15结合后复合物的晶体结构被成功解析出来，使之可以揭示Ash1L与Mrg15之间的特异相互作用以及Mrg15激活Ash1L的机理. 我们通过比较Ash1L/Mrg15复合物的两个晶体结构来讨论Ash1L分子中的天然无序区域在其活化过程中所起的重要调控作用.]]></description>
<pubDate>2019/12/20 16:17:15</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[YANG Jing,XIONG Jun-Wen and HUANG Yong-Qi]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>YANG Jing,XIONG Jun-Wen and HUANG Yong-Qi</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20190109]]></guid><cfi:id>3</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Metabolic Disorder of Ribose]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20190210]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2019/12/20 16:22:12</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[HE Rong-Qiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HE Rong-Qiao</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20190210]]></guid><cfi:id>2</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Scap-Insig-2-25HC complex and Regulation of intracellular]]></title>
<link><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20210035]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Abstract: The sterol regulatory element-binding protein (SREBP) pathway controls cellular homeostasis of sterols through a negative feedback mechanism. SREBP-cleavage activating protein (SCAP), and insulin-induced gene-2 (INSIG-2), 25-hydroxycholesterol (25HC) play an important role in regulating the activation, maturation, and nuclear translocation of SREBP. Recent studies have shown the structure of the SCAP-INSIG-2-25HC complex, which is important to the study of intracellular cholesterol metabolism.]]></description>
<pubDate>2021/4/26 9:53:57</pubDate>
<category><![CDATA[News and Views]]></category>
<author><![CDATA[tangshangshu,zhang min and tang chao ke]]></author>
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<atom:name>tangshangshu,zhang min and tang chao ke</atom:name>
</atom:author>
<guid><![CDATA[http://www.pibb.ac.cn/pibben/article/abstract/20210035]]></guid><cfi:id>1</cfi:id><cfi:read>true</cfi:read></item>
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