2015年第42卷第11期目录
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封面故事:作为遗传学的伴生学科,表观遗传学研究在基因核苷酸序列不发生改变的情况下基因表达和功能的可遗传变化.染色质重塑、DNA甲基化、X染色体失活、非编码RNA调控等都是表观遗传学的重要研究内容.近年来,表观遗传学已逐步发展成为生命科学领域的前沿热点学科,取得了丰硕的研究成果.在此背景下,本刊特邀朱冰研究员主持,围绕表观遗传学领域的重要科学问题,邀请国内多位在该领域研究取得突出成果的专家学者,以各自研究经验与专业视野为基础,撰写了综述论文,在此集萃成辑,以飨读者.本期封面图片选自李国红等撰写的综述论文,图片总结了30 nm染色质纤维结构的调控因素.
(梁 丹,陈 萍,李国红. 30 nm染色质纤维的结构及调控,本期第1009~1014页)
Cover Story:In eukaryotic cells, genomic DNA is hierarchically packed into chromatin by histones in the nucleus. Despite of over 30 years' study, the fundamental structure of 30 nm chromatin fiber remains controversial. In this review, we focus on recent progress in revealing the structure of 30 nm chromatin fiber, and emphasize on the most recent left-handed double helix structure of 30 nm chromatin fiber. In addition, we discuss the epigenetic regulation of the 30 nm chromatin structure. Finally, we discuss the possible challenge in elucidating the structure of 30 nm chromatin fiber and its regulation.
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表观遗传学专刊
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