2015年第42卷第7期目录

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封面故事:亚磁场环境是地外空间三大环境特征之一,在未来深空探测中,空间亚磁环境对航天乘员行为和健康的影响是不得不考虑的问题.莫炜川和付晶鹏等搭建了标准化的地面亚磁场模拟设备及动物饲养设施,并系统研究了30天亚磁场处理对成年小鼠行为和激素水平的影响,发现亚磁场中小鼠的昼夜饮水节律改变,后续伴随热敏痛觉耐受能力、整体活动水平和血清去甲肾上腺素水平降低,提示亚磁场下动物节律、血液激素的变化可能是感觉和行为异常的诱因.本文研究为进一步探究亚磁环境下动物运动及生理活动的变化和机制提供了新的线索和标准化的研究模型,并为亚磁场对空间乘员效应的评估、相应防护和应对措施的开发提供科学的指导和数据积累.
(莫炜川,付晶鹏,丁海敏,刘 缨,华 茜,赫荣乔. 亚磁场引起小鼠昼夜节律改变和热痛觉敏感增加,本期第639~646页)

Cover Story:It has been established that exposure in the hypomagnetic field (HMF), which is one of the environmental factor of outer space, has adverse effects on animal and human behavior and brain function. Thus, it is necessary to develop appropriate counteract strategy to avoid the HMF-induced risks to the health of the astronauts during long-term and long-distance manned space mission. However, the physical and mental effects of the HMF in details still await systematic evaluation and the underlying mechanism remains elusive, so far. In this study, we constructed an HMF animal rearing system (< 500 nT) and examined the effects of one-month HMF exposure on the circadian behavior, pain response and emotions in adult male C57BL/6 mice (4~6 weeks old, (20 ± 2) g). The control animals were reared in the geomagnetic field (GMF). The HMF-exposed animals exhibited a prolonged alteration of the circadian drinking rhythm and a decrease in general activity, accompanied with an increase in thermal hyperalgesia. But the HMF did not induce obvious depression-like and anxiety-related behaviors. The serum noradrenalin concentration in HMF-exposed mice significantly decreased. These findings indicate that the HMF disturbs the behavior rhythm and the function of endocrine system, which probably leads to the subsequently weakened activities of the animal.

综述与专论

涡旋磁纳米颗粒——崭新的生物医用磁性纳米平台吴建鹏,刘晓丽,张欢,张艺凡,骆艳娥,樊海明  [摘要][PDF][HTML]

内皮-间质转化与心血管疾病的研究进展张晶晶,游咏,李熠,桂庆军,冯聚玲,尹凯  [摘要][PDF][HTML]

生长分化因子11:TGF-β超家族的新成员李倩,郝志明  [摘要][PDF][HTML]

G-四链体与配体相互作用的研究方法进展魏强,屈锋,龚芮  [摘要][PDF][HTML]

研究报告

亚磁场引起小鼠昼夜节律改变和热痛觉敏感增加莫炜川,付晶鹏,丁海敏,刘缨,华茜,赫荣乔  [摘要][PDF][HTML]

听觉选择性注意的可塑性及其神经机制研究朱莉,郑奋,邓娟,闫铮,徐晓玲  [摘要][PDF][HTML]

奖赏记忆改善焦虑行为的小鼠模型及机制初探雷卓凡,王晋辉  [摘要][PDF][HTML]

技术与方法

利用AIMs分析亚洲9个绵羊群体的群体结构张媛媛,韩德平,邓卫东,毛华明,邓学工,邓学梅  [摘要][PDF][HTML]

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