Huang Yan-Xia,Zhou Fei-Fan,Zhou Ting,Xu Hao,Lin Dan-Ying,Qu Jun-Le.Application of multiphoton microscopic imaging in the research on brain disease[J].Progress in Biochemistry and Biophysics
Application of multiphoton microscopic imaging in the research on brain disease
投稿时间:2019-05-04  修订日期:2019-07-01
Key words:multiphoton microcopy imaging, brain disease, bio-optical imaging
Fund:国家自然科学基金,国家重点基础研究发展计划,广东省高等学校科技创新(重点)项目,广东省自然科学基金,深圳市基础研究项目
作者单位E-mail
黄燕霞 深圳大学物理与光电工程学院 1800282045@email.szu.edu.cn 
周非凡 深圳大学物理与光电工程学院 zhouff@szu.edu.cn 
周婷 深圳大学物理与光电工程学院  
许皓 深圳大学物理与光电工程学院  
林丹樱 深圳大学物理与光电工程学院  
屈军乐 深圳大学物理与光电工程学院 jlqu@szu.edu.cn 
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Abstract:
      Multiphoton microscopy is an important biomedical imaging modality with great potential in the diagnosis of various diseases, due to high resolution, low damage, and long-term imaging of living organisms. Especially for the research on brain diseases, multiphoton microscopy can be used to observe neuron,blood vessels,tumors, and their interactions, which can further reveal the pathogenesis of brain diseases and direct the developement of diagnosis and treatment methods. This review introduces the basic principles and characteristics of multiphoton microscopy, and its applications in the study of various brain diseases, such as Alzheimer's disease,stroke and tumor. We highlight recent achievements in brain diseases using multiphoton microscopy and give an outlook on the development of multiphoton microscopy that is expected to play a greater role in the study of brain diseases.
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