Vol.39,No.11,2012

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Cover Story:The chromatin assembly factor 1 (CAF-1) is a three-subunit protein complex that functions in chaperoning histone deposition. The smallest subunit of Drosophila CAF-1, dCAF-1-p55, together with the other two subunits dCAF-1-p180 and dCAF-1-p105, participates in the deposition of histone H3 and H4 onto the newly synthesized DNA. In addition to the CAF-1 complex, dCAF-1-p55 is also found in several other complexes such as NURF, PRC2 and Sin3-HDAC1 complex, suggesting that it plays multiple roles other than a histone chaperone. Here we report a new allele of dCAF-1-p55 generated by gene targeting. We show that dCAF-1-p55 loss-of-function led to developmental delay and lethality. Further investigations demonstrated that dCAF-1-p55 deficient cells exhibited defects in metaphase chromosome condensation, sister chromatids association and anaphase chromosomes segregation, which are premonitory signs of chromosome instability (CIN). Taken together, these results indicate that dCAF-1-p55 plays a role in the maintenance of chromosomal stability, likely to protect the cells from CIN and the proneness to cancer.

Reviews and Monographs

Computational Approaches to Analyze the Strategies of Drug RepositioningXIE Da-Fei,LI Peng,LI Fei,BO Xiao-Chen and WANG Sheng-Qi  [Abstract][PDF][HTML]

Cognitive and Neural Mechanisms of Probabilistic Category LearningLI Kai-Yun,FU Qiu-Fang and FU Xiao-Lan  [Abstract][PDF][HTML]

Advance in PUMA and Cardiomyocyte ApoptosisLI Yu-Zhen and LIU Xiu-Hua  [Abstract][PDF][HTML]

Research Papers

dCAF-1-p55 is Essential for Drosophila Development and Involved in The Maintenance of Chromosomal StabilityWU Qing-Hua,LIU Ji-Yong,CHEN Yi-Xu and JIAO Ren-Jie  [Abstract][PDF][HTML]

The Effect of Weak Background Noise on The Frequency Tuning of Neurons in The Rat Auditory CortexPENG Yin-Ting,PU Qing,SUN Xin-De and ZHANG Ji-Ping  [Abstract][PDF][HTML]

Stability and Glucose Regulation of FGF21 After Modified With ArgininesHE Kun,ZHANG Ya-Kun,YE Xian-Long,WANG Wen-Fei,CHEN Rui,LIU Ming-Yao,FENG Ming-Fang,XU Jia-Ling and LI De-Shan  [Abstract][PDF][HTML]

miR-30a Enriched Colostrum-Fraction Can Inhibit The DDP-induced Autophagy of HeLa Cells and Promote The Tumor ShrinkZOU Zhen-You,WANG Yang,DING Han-Ying,WU Lin-Ping,CHEN Shu-Mei,JIANG Ting,GUO Fang,ZHANG He-Yun,CHEN Xi,ZHANG Qi-Peng,ZENG Ke and ZHANG Chen-Yu  [Abstract][PDF][HTML]

Identification of Human Methyl-CpG Binding Domain Protein (MBD) 4 as a Substrate of Protein Kinase XLI Wei and LIN Ying  [Abstract][PDF][HTML]

New techniques

Methods and Progress of Mass Spectrometry-based Selected Reaction MonitoringCHANG Cheng,WU Song-Feng,MA Jie,ZHANG Wei and ZHU Yun-Ping  [Abstract][PDF][HTML]

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