Vol.40,No.11,2013

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Cover Story:Multiple sclerosis (MS), an autoimmune disease of the CNS with prominent demyelination and axonal degeneration, is more prevalent in women than men. EAE is a widely used animal model of MS for preclinical therapy development. In this report, a 29 days observation of the EAE model induced by MOG33-35 in C57BL/6 mice was performed. From the clinical course, we found no significant difference between male and female mice in the incidence and onset time, but males had a more serious disease score than that in females. And histological examination of spinal cord was performed at day 21 post-immunization. Compared with male mice, female mice had a dramatic increase of leukocyte infiltration in the spinal cord. Luxol fast blue staining also revealed enhanced demyelination in male mice compared to female mice. The CNS leukocyte infiltration was also quantified by flow cytometry analysis at day 19 post-immunization. The results again confirmed that the CD4 T cells accumulated in the CNS of EAE mice were increased in male mice. We further quantified the number of TH-1 and TH-17 cells in the CNS infiltrates and found that the absolute number of both TH-17 and TH-1 cells were significantly increased in male mice. Taken together, these data indicate that sex difference exists in EAE induced by MOG33-35 in C57BL/6 mice, and this will provided useful indications for further studies on the selection of animals in the EAE model.

Reviews and Monographs

Germline Stem Cells in Female Mammals: Moving on in ControversyCHEN Zhong-Liang and YANG Shi-Hua  [Abstract][PDF][HTML]

Patterns of Nucleosome and Chromatin Modifications and Their Effects on Chromatin StatesLIU Hong-De,LUO Kun,MA Xin,ZHAI Jin-Cheng,XIE Jian-Ming,SUN Xiao and WAN Ya-Kun  [Abstract][PDF][HTML]

An Analysis of Protein Bioinformatics Datasets Related to Lewy Bodies of Parkinson′s DiseaseCHEN Jia-Jun,TIAN Ming-Xiu,LI Xing-An and HU Lin-Sen  [Abstract][PDF][HTML]

Research Papers

Influence of Pseudomonas aeruginosa Autoinducer of Las on Murine Macrophage In vitroYANG Wang,CHEN Song,YANG Zhen-De,XIAO Xin and LIAO Fang  [Abstract][PDF][HTML]

Gender Influence on The Pathogenesis of EAE Induced by MOG in C57BL/6 MiceWANG Ting-Ting and DU Chang-Sheng  [Abstract][PDF][HTML]

Biological Effect of The Interaction Between Mental Retardation Related Protein (FXR1P) and CMASMA Yun,QIN Ling-Xue,DONG Xiao,LI Bin-Yuan,WANG Chang-Bo,XU Can,WANG San-Hu and HE Shu-Ya  [Abstract][PDF][HTML]

Inhibition of Highly Pathogenic Avian Influenza A Virus H5N1 Growth and Induction of Inflammatory Mediators by GeldanamycinHU Yi,LIU Peng-Peng,ZHANG Zhi-Ming,LU He-Zhen,LUO Jing,WANG Cheng-Min,LIU Jun-Xu,ZHAO Bao-Hua and HE Hong-Xuan  [Abstract][PDF][HTML]

The Expression Profiling of Rice Pathogenesis-related Proteins in Seedling Stage Under Environmental StressesGAO Qing-Hua,ZENG Xiang-Ran,JIA Lin,NIU Dong-Dong,LI Xue-Jiao,GUAN Ming-Li,JIA Meng,LAN Jin-Ping,DOU Shi-Juan,LI Li-Yun,LIU Li-Juan and LIU Guo-Zhen  [Abstract][PDF][HTML]

Identification and Function Reasearch of fabA and fabB of Sinorhizobium melilotiHU Zhe,MA Jin-Cheng,JIANG Jing-Jing and WANG Hai-Hong  [Abstract][PDF][HTML]

Electrode-mediated Rectification of The Differential Photocurrent Response of Dry Bacteriorhodopsin FilmXU Bing,HAN Jin-Duo,WANG Ao-Jin and HU Kun-Sheng  [Abstract][PDF][HTML]

His-234 is an Essential Residue for Populus tomentosa 4-coumarate ∶ CoA Ligase Enzymatic MechanismsREN Bai-Guang,LI De-Feng,ZHENG Cai-Xia,GAI Ying,JIANG Xiang-Ning and HU Yong-Lin  [Abstract][PDF][HTML]

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