Vol.41,No.2,2014

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Cover Story:Activity-dependent synaptic structural plasticity underlies the learning and memory. Mammals, especially the rodents, are very sensitive to odorants, and have considerable capability of odor learning and memory. Here, the activity-dependent synaptic structural plasticity in the olfactory bulb (OB) of the CNGA2 knock-out transgenic mice (CNGA2 KO), which is anosmic, was investigated. Using immunohistochemistry for specific presynaptic and postsynaptic markers, it was found that deficits of peripheral inputs induced significant decreases in the expression of synaptophysin, a general marker for synapses, and gephyrin, a marker for inhibitory synapses, in the external plexiform layer (EPL) and the granule cell layer (GCL), but the vesicular glutamate transporters 1 (VGluT1) decreased only in EPL, not in GCL. Western-blots showed the decreases in the expression of gephyrin in the OB of CNGA2 KO mice, but not in the expression of the VGluT1. The results of immunohistochemistry and Western blot revealed that the excitatory and inhibitory synapses may have changed after deficits of peripheral inputs. GCs were the main participants in the EPL and GCL in the OB. Dendritic spines are the postsynaptic sites of the majority of excitatory synapses in the mammalian central nervous system, and the morphology and dynamics of dendritic spines change in response to novel experiences and neuropathologies. In the OB, spines on mature GCs are recipients of glutamatergic synapses in the GCL and reciprocal synapses in the EPL. Almost all study related to structural plasticity of GCs concentrated on the adult-born GCs, but the number of new-born granule cells in the OB is negligible compared with the number of preexisting GCs.

Reviews and Monographs

Reconstruction of Whole Cell Network and Design of Cell FactoryXU Zi-Xiang,ZHENG Ping and SUN Ji-Bin  [Abstract][PDF][HTML]

Construction and Analysis of Dynamic Molecular NetworksLIU Wei and XIE Hong-Wei  [Abstract][PDF][HTML]

The Pivotal Roles of DUBs in Gene Expression ControlCHEN Yu-Han,ZHANG Ling-Qiang and HE Fu-Chu  [Abstract][PDF][HTML]

Ribonuclease-4: a Highly Conserved Multifunctional NucleaseSHENG Jing-Hao and XU Zheng-Ping  [Abstract][PDF][HTML]

Short Communications

Reduction of The Crowding Effect by Topological Difference Between Target and FlankersWU Rui-Jie,WANG Bo and ZHUO Yan  [Abstract][PDF][HTML]

Cloning and Functional Characterization of a Novel Long Non-coding RNA Gene Associated With Hepatocellular CarcinomaTANG Ke,WEI Fang,BO Hao,HUANG Hong-Bin,ZHANG Wen-Ling,GONG Zhao-Jian,LI Xia-Yu,SONG Ya-Li,LIAO Qian Jin,PENG Shu-Ping,XIANG Juan-Juan,ZHOU Ming,MA Jian,LI Xiao-Ling,XIONG Wei,LI Yong,ZENG Zhao-Yang and LI Gui-Yuan  [Abstract][PDF][HTML]

Research Papers

Peripheral Input-dependent Structural Plasticity of Granule Cells in The Mouse Olfactory BulbRAO Xiao-Ping,XU Zhi-Xiang,WANG Li and XU Fu-Qiang  [Abstract][PDF][HTML]

Orientation Selectivity of Onset and Offset Responses of Neurons in Primary Visual CortexDENG Chun-Shan and WANG Yi  [Abstract][PDF][HTML]

Multi-Pathways-Mediated Propagations of Intercellular Calcium Waves in Microglial CellsWU Xian,PAN Lei-Ting,LIU Ying,XING Meng-Xi,ZHANG Xin Zheng and XU Jing-Jun  [Abstract][PDF][HTML]

Role of miR-122 Targeting AldoA in The Metabolism of ob/ob MiceFANG Zhi-Juan,LI Peng,DIAO Wen-Li,JIANG Ting,ZHANG Chen-Yu and XIANG Yang  [Abstract][PDF][HTML]

Regulation of The Phosphorylation of Yeast Protein Kinase Sch9 Under Environmental Changes and During Chronological AgingLIU Jun,LV Lei,QIE Bei-Bei and LIU Ke  [Abstract][PDF][HTML]

The Study of HA Nanoemulsionloading MD-CPT by Transdermal Delivery Effect on Keloid RepairGAO Yuan-Yuan,KONG Ming,CHENG Xiao-Jie,WANG Zhi-Guo and CHEN Xi-Guang  [Abstract][PDF][HTML]

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