Vol.41,No.4,2014

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Cover Story:Gene regulatory networks have an important role in every process of life, including cell differentiation, metabolism, the cell cycle and signal transduction. The RASSF1A is a tumor suppressor gene involved in several growth regulatory and pro-apoptotic pathways. In this study, we have used microarray technology to define differences in the gene expression profiles subsequent to exogenous wild-type RASSF1A in melanoma A375 cells. Gene expression changes were verified in a subset of genes using real time RT-PCR. Association of modulated genes with biological functional groups identified several pathways affected by RASSF1A including cell death, cellular growth and proliferation, and cellular development. GRN of modulated genes were identified using the STRING. Pro-inflammatory factors and transcription factors locates in the center of RASSF1A modulated gene regulatory networks. Our results suggested that RASSF1A might affect melanoma gene regulatory network via modulating the expression and interaction between pro-inflammatory factors and transcription factors.

Reviews and Monographs

The Role of ATP Binding Cassette Transporter A1 in The Brain Disease DevelopmentOU YANG Xin-Ping,ZHANG Min,HE Ping-Ping,TANG Yan-Yan,LI Yuan and TANG Chao-Ke  [Abstract][PDF][HTML]

The Mechanism and Tumorigenesis of Oncogenic DNA Virus IntegrationYU Zheng-Yuan,SONG Ya-Li,GONG Zhao-Jian,ZENG Zhao-Yang,LU Jian-Hong,LI Xiao-Ling,XIONG Wei and LI Gui-Yuan  [Abstract][PDF][HTML]

Runx2 and Breast CancerFU Xiao-Zhen,LI Hong-Yan,ZHANG Ye-Jun,QU Chao,ZHONG Guang-Ying,LIU Jing and ZOU Wei  [Abstract][PDF][HTML]

Progress of The Research on NesprinsZHAO Chun-Xia,CUI Ying-Yu and CHEN Yi-Han  [Abstract][PDF][HTML]

Research Papers

Gene Network Modulated by RASSF1A Over-expression in Melanoma A375 CellsYI Mei,LI Ji,SU Juan,ZHANG Jiang-Lin,CHEN Xiang,DU Qian-Jun,XIANG Bo,XIONG Wei,LI Xiao-Ling and XIE Hong-Fu  [Abstract][PDF][HTML]

Inhibition of Hepatitis B Virus in Mice by Cationic Liposome/RNA Oligonucleotide ComplexZAN Yan-Lu and TIAN Bo  [Abstract][PDF][HTML]

Molecular Regulation of TRPC1 on The Toxicity mediated by α-synuclein in Multiple System AtrophyWANG Hai-Long,DENG Yu-Lin,ZHANG Ze-Bo,WANG Chen,YANG Zu-Ye,LI Fu-Tao and MA-Hong  [Abstract][PDF][HTML]

Catastrophe of Neuronal Activity in Rat Hippocampus During The Period of Deep Anesthesia Till Brain DeathCAO Jia-Yue,FENG Zhou-Yan,ZHENG Xiao-Jing and CHEN Bai-Lu  [Abstract][PDF][HTML]

HMGB1 Plays a Key Role in Acute AlcoholismCHEN Xiao-Bin,ZHU Wei-Bin,RUAN Lin-Hao and TANG Jie  [Abstract][PDF][HTML]

Techniques and Methods

Multiple States of Bacillus subtilis Revealed by Flow CytometryLIU Chun-Chun,ZHAO Yun and HANG Hai-Ying  [Abstract][PDF][HTML]

Enrichment and Characterization of Total N-linked Glycans From Glycoproteins by Ultrafiltration Units and Mass SpectrometryYANG Gang-Long,MA Tian-Ran and LI Zheng  [Abstract][PDF][HTML]

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