Vol.41,No.5,2014

Other Issues:  
  
 
Cover Story:FK506 binding protein 12.6 (FKBP12.6), a protein that binds to and regulates the ryanodine receptor type 2 (RyR2) Ca2+ release channels, may act as an important regulator of catecholamine secretion. In the present study, the role of FKBP12.6 in the control of chromaffin cell exocytosis has been investigated using FKBP12.6-null mice. The results showed that FKBP12.6 was expressed in mouse chromaffin cells; deletion of FKBP12.6 did not change the depolarization induced Ca2+ current and exocytosis. However, deletion of FKBP12.6 resulted in an enhanced caffeine-induced global Ca2+ transient and larger caffeine-induced exocytosis in chromaffin cells of mice. These results indicate that FKBP12.6 is involved in catecholamine secretion through regulation of Ca2+ release channel in mouse chromaffin cells.

Reviews and Monographs

The Progress in Phosphohistidine ResearchWANG Zhi-Peng,CHEN Chen-Chen,WANG Tian,WANG Miao and LI Yi-Ming  [Abstract][PDF][HTML]

Research Advances of The NLRP3 Inflammasome and Metabolic DiseaseLI Jin-Feng,XIE Di,HE Ping-Ping,TANG Yan-Yan,TU Yu-Lin and YIN Kai  [Abstract][PDF][HTML]

Uridylation of RNAXIE Zhao-Hui  [Abstract][PDF][HTML]

mTOR and S6K Play an Important Role in AgeingZHU Feng,MA Li-Wei and TONG Tan-Jun  [Abstract][PDF][HTML]

Short Communications

FKBP12.6 Regulates The Secretion of Adrenal Chromaffin Cell in MiceYUAN Qi,GUO Ning,GU Lei,WANG Jun,WANG Li,ZHOU Zhuan and JI Guang-Ju  [Abstract][PDF][HTML]

Research Papers

The E(spl) and Su(H) of Notch Signaling Are Required for Regulating of Drosophila Innate ImmunityWANG Xiao-Chun and JIN Li-Hua  [Abstract][PDF][HTML]

An Investigation on Characteristic of Residues Involved in Intrinsically Disordered Protein-Protein InteractionDONG Chuan,CAO Zan-Xia,ZHAO Li-Ling,SUO Zhen-Peng and WANG Ji-Hua  [Abstract][PDF][HTML]

E92A Is an Activity Recovery Mutation of HIV-1 Integrase Drug Resistance Mutation N155SLI Shan,LIU Bin,LI Chun-Hua,TAN Jian-Jun,ZHANG Xiao-Yi and WANG Cun-Xin  [Abstract][PDF][HTML]

The Changes of Spike Propagation Fidelity During Postnatal Development in Cerebellar Purkinje CellsYANG Zhi-Lai and WANG Jin-Hui  [Abstract][PDF][HTML]

Paraoxonase-1 Mediates Hydrogen Sulfide-induced Protection Against Formaldehyde NeurotoxicityZHANG Ping,LI Xiang,REN Yan-Kai,WANG Chun-Yan,ZOU Wei and TANG Xiao-Qing  [Abstract][PDF][HTML]

Development of Quantum Dot-Based Lateral Flow Immunoassay System for Rapid Quantitative Detection of Human Chorionic GonadotropinYANG Qiu-Hua,WANG Xin,YANG Jiu-Min,LI Xue,SONG Tao,GONG Xiao-Qun,ZHANG Bing-Bo and CHANG Jin  [Abstract][PDF][HTML]

Characterization of Interaction Protein for Osteosarcoma Related Protein IEX-1LIU Li-Hong,LI Hui,LI Jie,OUYANG Yu-Rong,GUO Hon-Bin,CUI Yun-He,LIU Ying-Qi and XIAO Tao  [Abstract][PDF][HTML]

Techniques and Methods

A Novel Bicistronic Expression Strategy for Neuronal Calcium Imaging in C. elegansZHANG Hai-Ning,HUANG Wen-Ming,YANG Song and XU Tao  [Abstract][PDF][HTML]

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