Vol.41,No.9,2014

Other Issues:  
  
 
Cover Story：Kinesin-3 KIF1A is responsible for the anterograde transport of synapse vesicle (SV) precursors in axons. The CC1-FHA tandem of KIF1A has been revealed as a stable dimer that can trigger motor activity, but the mechanism underlying the regulation of the CC1-FHA dimer is unclear. Based on the CC1-FHA dimer structure, we found a potential phosphorylation motif "487SPKK490" located at the dimer interface. We demonstrated that the phosphorylation-mimetic mutation of Ser487 leads to the dissociation of the CC1-FHA dimer. Moreover, the Ser487-mutation could regulate the motor activity of KIF1A and the KIF1A-mediated axonal transport activity of SVs in C. elegans. Thus, the highly conserved "487SPKK490" motif may be a key site in the CC1-FHA tandem for regulating CC1-FHA dimerization and the subsequent activity of KIF1A.

Reviews and Monographs

Progress in The Studies on Synaptic and Extrasynaptic NMDA Receptors and The Roles in Alzheimer′s DiseaseLI Xing-Yu and GAO Can  [Abstract][PDF][HTML]

cGAS-STING: The Novel Mechanism of Cytosolic DNA Sensing PathwaysDING Liang,NI Yan-Hong,HU Qin-Gang and HOU Ya-Yi  [Abstract][PDF][HTML]

Research Advances on The New Epigenetic Marker: 5-HydroxymethylcytosineGE Miao-Miao and CAI Chun  [Abstract][PDF][HTML]

Molecular Integrators of Neuropathy and Pain in Diabetes MellitusSTOYANOV Stoyan B.,LENTZ Soren L.,VALDES-HERRERA Jose P.,KRASTEV Nikolai S. and KRASTEV Dimo S.  [Abstract][PDF][HTML]

Short Communications

The Effect of Attentional Task and Task Difficulty on Microsaccades in MacaquesYE Jing-Ying,XUE Lin-Yan,HUANG Dan,YANG Yue-Jiao and CHEN Yao  [Abstract][PDF][HTML]

Research Papers

Potential Phosphorylation Site Modulates The Dimerization and Activity of KIF1ALIU Bei,YUE Yang,YU Yong,REN Jin-Qi,FENG Wei,HUO Lin and XU Tao  [Abstract][PDF][HTML]

Molecular Regions Determining The Voltage-dependence of Inactivation for T-type Calcium Channel Cav3.1HE Bing-Jun,HU Fen,SHANG Xue-Liang,HAN Li-Xin,WU Guang-Yan,LI Jun-Ying and SUN Jin-Sheng  [Abstract][PDF][HTML]

Identification and Function Reasearch of Five 3-Ketoacyl-ACP Synthase HomologuesMA Jin-Cheng,DENG Li-Ting,TONG Wen-Hua,ZHU Lei and WANG Hai-Hong  [Abstract][PDF][HTML]

Effects of Temperature on The Growth and Nitrate Reductase Activity of Chaetoceros curvisetus and Karenia mikimotoiDAI Ai-Quan,SHI Xiao-Yong,DING Yan-Yan,TANG Hong-Jie,WANG Li-Sha and WANG Xiu-Lin  [Abstract][PDF][HTML]

The Hierarchical Importance of Components of The Peptide-loading ComplexNIU Ge,MA Juan,LIU Chang-Zhen,MA Pan,HAN Hua-Min,ZHAO Yun-Feng,ZHANG Ge,TAO Hua and GAO Bin  [Abstract][PDF][HTML]

Techniques and Methods

The Detection of cTnⅠ by The Aptamer BiosensorJIANG Shu-Hai,FAN Ting,LIU Li-Juan,CHEN Yi,ZHANG Xiao-Qing,SHA Zuo-Liang,LIU Yu-Liang and ZHANG Juan-Kun  [Abstract][PDF][HTML]
©：Progress in Biochemistry and Biophysics
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