Vol.44,No.5,2017

Other Issues:  
  
 
Cover Story:Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic function that provide the first line of host defence against microbial infection and tumors. NK cells are now considered to be an important part of the immune system by controlling microbial infections and tumor progression. Although they were discovered more than 40 years ago, NK cells have recently been attracting attention for their potential in immune-based therapies. Over the past few years many researchers have reported that NK cells as one of the main effector cells of the innate immune system, their activity and function are greatly influenced by the cell surface protein glycosylation modification and glycan-binding proteins (e.g. siglec, selectin and galectin) located on the surface of cells. For example, the immune evasion mechanisms from NK immunity using cell-surface glycans have been identified. The cancer cells use the certain types of cell-surface glycans to evade NK immunity, such as reducing NK activating receptor-mediated signaling, enhancing NK inhibitory receptor-mediated signaling, and modulating TRAIL-mediated killing. In addition, such siglec interacts with sialic acid-overexpressing cells to lead to inhibition of NK cells activation. Selectin combines with ligand to promote the immune function of NK cells. Galectin binds β-galactosides to mediate NK cells immune process. This review summarizes the recent progress of the certain types of glycans and glycan-binding proteins related to the immunological function of NK cells, and discusses the influence of abnormal glycan-binding proteins for the development of tumor, as well as their application prospect in immune-based therapies.

Reviews and Monographs

New Progress of Glycan-binding Proteins Related to NK CellsYANG Jia-Jun, LIU Xia-Wei, SHU Jian, ZHANG Kun and LI Zheng  [Abstract][PDF][HTML]

Ubiquitination in DiseasesFANG Shuai and ZHAO Bo  [Abstract][PDF][HTML]

The Ownership Effect in Human’s Memory and Its Cognitive and Neural MechanismsLI Zhan-Xing and ZHU Li-Qi  [Abstract][PDF][HTML]

Roles of Reactive Nitrogen Species in Ischemic StrokeZHANG Pan, YAN Wei-Jie and ZHAO Yu-Ming  [Abstract][PDF][HTML]

Short Communications

Abnormal Attentive Tracking in Children With Intermittent ExotropiaZHOU Li-Qin, ZUO Zhen-Tao, WANG Jing, FU Tao and CHEN Lin  [Abstract][PDF][HTML]

Research Papers

Crystal Structure of EspB From Mycobacterium tuberculosis: Insights on Possible Secretion Mechanism of ESX-1 PathwayTANG Xiao-Meng and WANG Da-Cheng  [Abstract][PDF][HTML]

Hepatocytes Express IL-2 In vitro in The Presence of Both HBx Stimulation and Mild Oxidative StressGAO Dong-Mei, ZHAO Yue, CHEN Jie, ZHAO Yan, CHEN Jun and ZHOU Hai-Jun  [Abstract][PDF][HTML]

A “Self-checking” Algorithm for Accurate Detection of High-density and Fast-moving Vesicles in Time-series Fluorescence ImagesZHANG Xiang, LIU Xin-Yi, LV Ping-Ping and JIA Ce  [Abstract][PDF][HTML]

Techniques and Methods

Inferring Gene Regulatory Networks Based on Ordered Conditional Mutual Information and Limited Parent NodesLIU Fei, ZHANG Shao-Wu and GAO Hong-Yan  [Abstract][PDF][HTML]

©:Progress in Biochemistry and Biophysics
Responsible Institution:中国科学院Organizers:Institute of Biophysics, The Chinese Academy of Sciences; Biophysical Society of ChinaAddress:15 Datun Road, Chaoyang District,Beijing 100101,China
Tel:86-10-64888459Email:prog@ibp.ac.cn
Support:Beijing E-Tiller Co.,Ltd.