Vol.44,No.6,2017

Other Issues:  
  
 
Cover Story:Dysmetabolism of endogenous formaldehyde is regarded as one of the risk factors for the onset and progression of Alzheimer’s disease. Excess extracellular and intracellular formaldehyde induce neuron death, involving the impairment of cognitive ability. As previously reported, lysosome dysfunction plays an important role in neurodegenerative diseases and intracellular formaldehyde locates in the lysosome. Utilizing formaldehyde fluorescent probe, abnormally increase of the lysosomal formaldehyde was detected in the blood endothelial cell line (bEnd.3) and neuroblastoma N2a cells (N2a) from mouse brain under oxidative stress. Brain formaldehyde was significantly (P < 0.01) elevated in the chronic cerebral hypoperfusion rats compared with those with SHAM. LeuLeuOMe was used to induce the permeabilization of lysosome membrane in bEnd.3. After LeuLeuOMe tretment, higher intracellular and lower extracellular formaldehyde were measured by microplate reader and high performance liquid chromatography (HPLC) respectively. In other words, lysosome not only accommodates endogenous formaldehyde, but also transports the compound out of cells. Abnormal lysosome function causes dysmetabolism of formaldehyde, which is correlated with age-related cognitive impairment.

Reviews and Monographs

The Progress in Identifying of The Behavioral and Neurobiological Characteristics of Emotional Dysfunction and Its Integrated Clinic Intervention Strategies in Methamphetamine AddictsWANG Chun-Guang, YUAN Ming, LUO Gui-Ling, LI Yong-Hui and SUI Nan  [Abstract][PDF][HTML]

The Progress of Genetics for Non-obstructive AzoospermiaTU Chao-Feng, YUAN Shi-Min, MENG Lan-Lan, LUO Ai-Xiang and TAN Yue-Qiu  [Abstract][PDF][HTML]

The Molecular Mechanisms of Mitochondrial Unfolded Protein ResponseFAN Yu-Mei, HAO Qiang, LIU Si-Ying, CHANG Yan-Zhong, DUAN Xiang-Lin and TAN Ke  [Abstract][PDF][HTML]

Short Communications

Effect of Oxidative Stress on Accommodation and Transportation of Formaldehyde by LysosomeCHEN Xi-Xi, SU Tao, HE Ying-Ge and HE Rong-Qiao  [Abstract][PDF][HTML]

Research Papers

Cre-miR914 Regulates Heat Shock Adaptation in Chlamydomonas reinhardtiiZHANG Feng-Ge, WANG Bo, WANG Xiao-Lin, LI Xiao-Yan, LI Gen-Bao, LI Dun-Hai, SHAN Ge and WANG Gao-Hong  [Abstract][PDF][HTML]

MiR-26b Acts as a Tumor Suppressor microRNA in Prostate CancerDaguia Zambe John Clotaire, WANG Yun-Fei, HUANG Wei-Wei, ZHAO Fei, ZHANG Bin and LEI Ming  [Abstract][PDF][HTML]

Techniques and Methods

Electrophysiological Study of Synaptotagmin Ⅰ Deletion Using CRISPR/Cas9YANG Bo, ZHENG Yi, LU Si-Yao and YAO Jun  [Abstract][PDF][HTML]

A Modelling and Simulation Study of Drug Effects on Short QT SyndromeLUO Cun-Jin, WANG Kuan-Quan and ZHANG Heng-Gui  [Abstract][PDF][HTML]

Letter to Editor

Study on The Relationship of Laser Power Density and Localization Precision in PALM ImagingFAN Chun-Yan, LI Yuan-Yuan, GU Lu-Sheng, LI Wei-Xing, XU Xiao-Jun, ZHANG Shu-Wen, WANG Lei, CHEN Yan, XUE Yan-Hong and JI Wei  [Abstract][PDF][HTML]

©:Progress in Biochemistry and Biophysics
Responsible Institution:中国科学院Organizers:Institute of Biophysics, The Chinese Academy of Sciences; Biophysical Society of ChinaAddress:15 Datun Road, Chaoyang District,Beijing 100101,China
Tel:86-10-64888459Email:prog@ibp.ac.cn
Support:Beijing E-Tiller Co.,Ltd.