Vol.45,No.11,2018

Other Issues:  
  
 
Cover Story：The investigation about chromatin 3D structure is becoming one indispensable way in studying genome functions and gene regulation. In past several years, thanks to the development of chromatin conformation capture technology and decreasing cost of high throughput sequencing, the amount of whole-genome interaction data increases rapidly with the ascending resolutions. This not only brought the chances for interpreting 3D genome, but also challenged the modeling methods. Nowadays, methods of analyzing these data covered a wide range, including pre-processing, normalization, visualization, features extraction and 3D modeling; however, choosing efficient and precise computational methods becomes an obstacle limiting the study of 3D genome. In this paper, we sum up these methods according to their suitable conditions, principles and characters and focus on the methods for new technologies and requirements in order to promote the application and development of these methods, assisting the investigation of 3D genome.

Reviews and Monographs

The Advancement of Analysis Methods of Chromosome Conformation Capture DataZHANG Xiang-Lin, FANG Huan and WANG Xiao-Wo  [Abstract][PDF][HTML]

Applications of Multiparametric Imaging Atomic Force Microscopy in Probing Cellular and Molecular MechanicsLI Mi, XI Ning, WANG Yue-Chao and LIU Lian-Qing  [Abstract][PDF][HTML]

microRNAs Act as Regulators of Autophagy in Cardiovascular DiseaseZENG Zhao-Lin, CHEN Jiao-Jiao and WANG Zuo  [Abstract][PDF][HTML]

The Role of lncRNA as Competitive Endogenous RNA in Non-Small Cell Lung CancersPAN Jin-Chang, MENG Xiao-Dan and GONG Zhao-Hui  [Abstract][PDF][HTML]

Transgenerational Inheritance of Mammalian Acquired Characteristics via Spermatozoal RNAsFU Bo, MA Hong and LIU Di  [Abstract][PDF][HTML]

Functions of Retinoic Acid in Heart Development and Cardiac Lineage DifferentiationLEI Wei, MIAO Shu-Mei, QIN Nian-Ci, DING Nan, HAN Xing-Long and ZHAO Zhen-Ao  [Abstract][PDF][HTML]

Research Papers

Investigation of Antibacterial Activity and Mechanism of Yb3+-Catechin ComplexYU Kang, LIU Lu, LI Ke, YANG Xi, LI Xia, LIAO Xue-Pin and SHI Bi  [Abstract][PDF][HTML]

Techniques and Methods

Assessment of Quality of Tri-allelic Polymorphism Compassing rs6983267 Based on Droplet Digital PCR Taking Advantage of Probe Cross-reactivitySHEN Yang-Li, SUN Hao, CAI Wen-Chen, ZHANG Pin-Zheng, WANG Xu-Ying, SHANG Yu-Han, SHI Lu, XIN Qian-Qian and GUO Zhi-Yi  [Abstract][PDF][HTML]

CorTectorTM SX100：Principles and Applications of ａ Bench-top Fluorescence Correlation SpectrometerWANG Zhu-Lou, KANG Ning, LIANG Yan-Qin, XIAO Qian and HUANG Shao-Hui  [Abstract][PDF][HTML]

News and Views

Immunotherapy targeted to immune checkpoint: a revolutionary breakthrough in cancer therapyJIANG Xian-Jie, WANG Jie, DENG Xiang-Ying, LI Xiao-Ling, LI Xia-Yu, ZENG Zhao-Yang, XIONG Wei, LI Gui-Yuan, XIONG Fang and GUO Can  [Abstract][PDF][HTML]
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