Vol.45,No.5,2018

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Cover Story:The default mode network (DMN) has been reported to be involved in a variety of important cognitive functions and received increasing attention in neuroscience recently. Its dysfunction is also reported to be associated with multiple psychiatric disorders. However, the causal information flow (effective connectivity) within the default mode network remains poorly understood. In this study, we explored the effective connectivity pattern between 4 key DMN brain areas based on a high resolution 7T resting state fMRI dataset using a cutting-edge spectral dynamic causal modelling technique. Results showed that there was a distinct effective connectivity pattern among the DMN nodes. We found medial prefrontal cortex(MPFC) and bilateral inferior parietal cortex(IPC) sent information to the posterior cingulate cortex(PCC), which suggested that the PCC might be a hub region that collected information from other DMN areas. Besides, a causal influence was found from bilateral IPC to MPFC, and from left IPC to right IPC. This work was the first 7T fMRI study that investigated effective connectivity pattern among DMN nodes, which may promote our understandings about the functions of DMN and benefit future research in DMN-related psychiatric disorders.

Reviews and Monographs

Research Progress on Epigenetic Regulation of rDNA TranscriptionCHENG Xiang-Rong, WEI Yan-Jun, HUANG Xing-Wei, WANG Nan, JIANG Qi, LIU Hui and LEI Lei  [Abstract][PDF][HTML]

Cellular Senescence and Tumor TherapyYUAN Fu-Wen and TONG Tan-Jun  [Abstract][PDF][HTML]

Research Progress of Mitochondrial Quality Control Dysregulation Involving in Carcinogenesis and Tumor ProgressionLIU Yao, HE Xing-Bo, ZHENG Hong-Yi and HUANG Cai-Bin  [Abstract][PDF][HTML]

The Progress of Cell Cycle Cdk1 Inhibitors in Budding YeastLIU Xue-Qin, REN Ping, ZHANG Ze and ZENG Fan-Li  [Abstract][PDF][HTML]

Advances in Applications of Ascorbate Peroxidase in Electron Microscope Imaging and Proximity Labeling in Live CellsXU Xiao-Jun, ZHU Xin-Yu, ZHANG Rui, XUE Yan-Hong, LI Zhen-Zhen, SONG E-Li and HOU Jun-Jie  [Abstract][PDF][HTML]

Cell-FET Sensors and Their Potential ApplicationBAO Jia-Li and FU Qi-Feng  [Abstract][PDF][HTML]

Short Communications

Directed Graph of Human Brain’s Default Network: a DCM With 7T fMRIZHANG Xian-Chang, XUE Rong and ZUO Zhen-Tao  [Abstract][PDF][HTML]

Research Papers

The Role of miR-33s in ABCA1 Expression and Cholesterol Efflux Suppression Induced by Nuclear Factor-kappaBCHEN Jun, JIANG Ting, LI Meng-Qi and ZHAO Guo-Jun  [Abstract][PDF][HTML]

Techniques and Methods

Affinity Electrophoresis for The Rapid Identification and Characterization of Substrate Binding Ability Influenced by Amino Acid Single-Point Mutation in Active-Site Architecture of Glucoside HydrolaseWU Xiu-Yun, LIU Shu-Ping, ZHAO Yue, CHEN Guan-Jun and WANG Lu-Shan  [Abstract][PDF][HTML]

©:Progress in Biochemistry and Biophysics
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