Vol.45,No.7,2018

Other Issues:  
  
 
Cover Story:The heat shock protein 90 (Hsp90) plays an important role in growth and progression of tumor cells through the appropriate folding, conformational maturation and activation of several hundred protein substrates (client proteins). Thus, Hsp90 attracts a great many of interests as a promising target for antitumor drugs which results in more than 20 inhibitors advancing to clinical trials. Here, we designed and synthesized a small molecule inhibitor: FS36 and the X-ray diffraction data of the complex crystal of Hsp90N-FS36 is collected. High-resolution X-ray crystallography shows that FS36 interacts with Hsp90N at the ATP-binding pocket and this demonstrates that FS36 possibly substitutes nucleotides to bind to Hsp90N. The complex crystal structure and the interactions between FS36 and Hsp90N lay the foundation of the design and majorization of novel antitumor drugs.

Reviews and Monographs

Progress in The Study of Giomagnetic Responses of OrganismsHE Jing-Lan, WAN Gui-Jun, ZHANG Ming, PAN Wei-Dong and CHEN Fa-Jun  [Abstract][PDF][HTML]

The Advance of YAP Regulating Epithelial-mesenchymal Transition in CellsSU Guan-Yue, YU Hong-Chi, HUANG Wen-Wen, WANG Ren-Yi, HU Yi-Qing, SHEN Yang, WANG Yun-Bing and LIU Xiao-Heng  [Abstract][PDF][HTML]

The Neural Mechanisms of Social PainWANG Yi-Le and ZOU Lai-Quan  [Abstract][PDF][HTML]

Research Papers

The Response Properties and Physiological Mechanism of Processing Doppler-shift Compensation Signal of The Single-on and Double-on Neurons in The Inferior Colliculus of Hipposideros prattiWANG Qiao-Chao, KONG Hui-Fang, CHENG Ya-Wen, WANG Hui-Mei, FU Zi-Ying, CHEN Qi-Cai and TANG Jia  [Abstract][PDF][HTML]

Discovery of FS36 as a Novel Human Hsp90 InhibitorLI Gen, LV Kai-Kai, LI Jian, YIN Xiu-Shan, ZHAO Dong and ZHANG Wan-Zhong  [Abstract][PDF][HTML]

LncRNA MIR31HG Inhibits The Proliferation of Esophageal Squamous Cell Carcinoma Cells by Inducing Cell Cycle ArrestCHEN Xiao-Qi, CHEN Xin-Ju, ZHANG Chuan-Lei, WANG Xin-Ting and YI Ai-Ying  [Abstract][PDF][HTML]

Roles of Excessive C3aR Signaling in The Kidney Damage of Patients With Diabetic NephropathyZHENG Jing-Min, CHEN De-Jun, YIN Guang, ZHAO Wen-Jin, LI Li-Juan and WANG Jian-Ping  [Abstract][PDF][HTML]

Techniques and Methods

Experimental Study of Microfluidic Chip for Cryopreservation of OocytesZHOU Xin-Li, GUO Ying-Ying, YI Xing-Yue, DAI Jian-Jun and ZHANG De-Fu  [Abstract][PDF][HTML]

New techniques

Application of Urine Proteomics in The Diagnosis and Treatment of Bladder CancerHUANG Chuan-Xi, MA Jie, XU Kai-Kun, WU Chen and ZHU Yun-Ping  [Abstract][PDF][HTML]

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