Chen Ji-Wu,WANG Bang-Zheng,Gao Xiu-Xia,Zhang Yuan-Yuan.Crosstalk between Autophagy and Proteasome Systems[J].Progress in Biochemistry and Biophysics
Crosstalk between Autophagy and Proteasome Systems
Received:June 12, 2012  Revised:December 11, 2012
Key words:autophagy-lysosome system,ubiquitin-proteasome system,ubiquitin, degradation, crosstalk
Fund:国家自然科学基金 (31071875) 资助项目
Author NameAffiliationE-mail
Chen Ji-Wu School of Life Science , East China Normal University jwchen@bio.ecnu.edu.cn 
WANG Bang-Zheng School of Life Science , East China Normal University 51101300079@ecnu.cn 
Gao Xiu-Xia School of Life Science , East China Normal University xiuxiagao1102@163.com 
Zhang Yuan-Yuan School of Life Science , East China Normal University zyyyf2008@126.com 
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Abstract:
      The two major degradation pathways of eukaryotic cells, autophagy-lysosome and ubiquitin-proteasome systems, have been found. The two degradation pathways were, for a long time, regarded as independent degradation pathways. However, recent evidence strongly suggest that there is crosstalk between the two degradation pathways. For example, perturbations either pathway have been reported to affect the activity of the other pathway. And inhibition of proteasome may stimulate autophagy activity. The roles of ubiquitin are also found far more than previously imagined. Ubiquitin not only has “traditional function” targeting proteins for proteasome degradation, but also is involved in ubiquitylating substrates for degradation of autophagy-lysosome system. So ubiquitin is a common tag of these main degradation pathways. These degradation systems share certain substrates and regulators, and show coordinated and, in some contexts, compensatory function. The coordinated and compensatory relationship between these degradation systems becomes critical in many cellular processes. Therefore, abnormities in these degradation systems involves not only aberrant cellular functions but also occurrence and development of many diseases. Understanding functions and crosstalk of these major degradation pathways will provide further insights into the repertoire of these degradation pathways, help to understand diverse cellular processes and facilitate our development of related new drugs.
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