LI Yu-Zhen.Research Progress on BMF Proapoptosis*[J].Progress in Biochemistry and Biophysics
Research Progress on BMF Proapoptosis*
Received:October 12, 2016  Revised:July 01, 2017
Key words:BMF, pro-apoptotic protein, cell apoptosis  
Fund:国家自然科学基金
Author NameAffiliationE-mail
LI Yu-Zhen Department of Pathophysiology,Institute of Basic Medical Science,PLA General Hospital yuzlif96@163.com 
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Abstract:
      Bcl-2–modifying factor (BMF) is a member of the BH3-only family of proapoptotic proteins. Under physiological conditions, BMF is sequestered to the cytoskeleton by association with dynein light chains 2, which prevents BMF to induce cell apoptosis. Some damage stimuli can release BMF from the cytoskeleton, allowing it to translocate to mitochondria and initiate mitochondrial apoptosis pathway. The proapoptotic activity of BMF is regulated at the transcriptional, translational and posttranslational levels. The upregulated and overexpressed BMF is also located predominantly in mitochondrial membranes that is consistent with its ability to induce cell death. Therefore, BMF is a powerful inducer of apoptosis.
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