HUANG Ying-Cong,MA Feng-Sen,ZHAN Hao-Hui,ZHANG Jie.Microneedle array used for transdermal delivery of biomacromolecules[J].Progress in Biochemistry and Biophysics
Microneedle array used for transdermal delivery of biomacromolecules
Received:May 09, 2017  Revised:August 04, 2017
Key words:biomacromolecule drugs,microneedles arrays,transdermal drug delivery,applications
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Author NameAffiliationE-mail
HUANG Ying-Cong Biologics and Biomaterials Laboratory,College of Pharmaceutical Science,Zhejiang University of Technology zero_yc_huang@163.com 
MA Feng-Sen Biologics and Biomaterials Laboratory,College of Pharmaceutical Science,Zhejiang University of Technology merrigen@126.com 
ZHAN Hao-Hui Biologics and Biomaterials Laboratory,College of Pharmaceutical Science,Zhejiang University of Technology  
ZHANG Jie Biologics and Biomaterials Laboratory,College of Pharmaceutical Science,Zhejiang University of Technology  
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Abstract:
      It’s difficult for biomacromolecules to permeate the barrier of the stratum corneum.Microneedles as a minimally invasive, painless, convenient transdermal drug delivery system could greatly promote the transdermal rate and absorption of biological macromolecules.In this paper, the advances in the application of microneedles loaded with biomacromolecule drugs were reviewed in detail,including the promotion of biomacromolecules by individual microneedle arrays (e.g. solid microneedles, hollow microneedles, coated microneedles and soluble microneedles) and combination of microneedles and other pharmaceutic techniques (such as microparticle delivery system), medical devices and intelligent drug-release system . At last,the current problems of microneedle are summarized, and the prospect of microneedle in the field of macromolecular drug delivery is forecasted.
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