Review: Cryogenic Super-resolution Correlative Light and Electron Microscopy(csCLEM)：New Challenges and New Opportunities

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Review: Cryogenic Super-resolution Correlative Light and Electron Microscopy(csCLEM)：New Challenges and New Opportunities
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Affiliation:Institute of Biophysics, Chinese Academy of Sciences,Institute of Biophysics, Chinese Academy of Sciences,College of Life Science and Technology, Huazhong University of Science and Technology,National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences,University of Chinese Academy of Sciences,Institute of Biophysics, Chinese Academy of Sciences
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Fund Project:This work was supported by a grant from The National Natural Science Foundation of China (31127901)

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Abstract:

Cryogenic super-resolution correlative light and electron microscopy (csCLEM)has been rapidly developed in recent years. This imaging methodology combines the specific labeling of fluorescence microscopy and the ultra-high resolution of electron microscopy, providing a new tool for resolving cellular structures in situ. It has the potential to become the next generation of imaging method. In this article, csCLEM was reviewd based on its historical background, application fields, development prospects, etc.

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LI Wei-Xing, GU Lu-Sheng, XU Xiao-Jun, XUE Yan-Hong, JI Wei, XU Tao.Review: Cryogenic Super-resolution Correlative Light and Electron Microscopy(csCLEM)：New Challenges and New Opportunities[J]. Progress in Biochemistry and Biophysics,2018,45(9):957-960

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Received:July 16,2018
Revised:July 16,2018
Accepted:August 03,2018
Online: September 17,2018
Published: September 20,2018

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