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FU Bo,MA Hong,LIU Di.Transgenerational Inheritance of Mammalian Acquired Characteristics via Spermatozoal RNAs[J].Progress in Biochemistry and Biophysics
Transgenerational Inheritance of Mammalian Acquired Characteristics via Spermatozoal RNAs
Received:March 30, 2018  Revised:August 22, 2018
Key words:sperm,small  non-coding  RNA,epigenetic, transgenerational  inheritance
Fund:黑龙江省农业科学院引进博士研究项目(201507-32) ,黑龙江省博士后科研启动金项目(LBH-Q15130),黑龙江省农业科学院国家自然科学基金培育项目,国家自然科学基金项目(31872980,31671289,31201804),国家生猪产业体系岗位科学家(CARS-37),黑龙江省科研机构创新能力提升专项(YC2016D001),“十二五”农村领域国家科技计划课题(2015BAD03B02-5)资助项目
Author NameAffiliationE-mail
FU Bo Institute of Animal Husbandry Research,HeiLongJiang Academy of Agricultural Sciences,Key Laboratory of crop and livestock molecular breeding in Heilongjiang Province fubohao810@163.com 
MA Hong Institute of Animal Husbandry Research,HeiLongJiang Academy of Agricultural Sciences,Key Laboratory of crop and livestock molecular breeding in Heilongjiang Province  
LIU Di Institute of Animal Husbandry Research,HeiLongJiang Academy of Agricultural Sciences,Key Laboratory of crop and livestock molecular breeding in Heilongjiang Province liudi1963616@163.com 
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Abstract:
      With the rapid development of epigenetics, there has been increasing concern with Lamarck’s theory of evolution which shed light on the inheritance of acquired characteristics. In recent years, transgenerational inheritance of mammalian acquired characteristics has also been investigated in detail. Epigenetic information, induced by environmental stresses, is transmitted through the germline during transgenerational inheritance of mammalian acquired characteristics. Spermatozoal sncRNAs play a key role in the establishment of epigenetic information which is associated with environmental stresses and function during transmission of epigenetic information. The environmental stresses related epigenetic information, embodied in sncRNAs, is stored in the mature spermatozoa. Subsequently, spermatozoal sncRNAs is involved in epigenetic modification in primordial germ cells after fertilization. Then these epigenetic modifications can be transmitted between generations, thereby affecting the expression of genes which are associated with acquired characteristics. In this paper, we review the mechanism through which spermatozoal sncRNAs participate in transgenerational inheritance of mammalian acquired characteristics, providing new ideas to investigate hereditary metabolic diseases or to promote human reproductive health and livestock breeding.
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