Zhang Xiang-Lin,Fang Huan,Wang Xiao-Wo.The Advancement of Analysis Methods of Chromosome Conformation Capture Data[J].Progress in Biochemistry and Biophysics
The Advancement of Analysis Methods of Chromosome Conformation Capture Data
Received:April 04, 2018  Revised:June 21, 2018
Key words:Hi-C, three-dimensional genomics, genome architecture, bioinformatics
Fund:国家自然科学基金(31371341, 61773230, 61721003),清华大学自主科研项目(20141081175)
Author NameAffiliationE-mail
Zhang Xiang-Lin Department of Automation, Center for Synthetic and Systems Biology, Tsinghua University
Ministry of Education Key Laboratory of Bioinformatics
Bioinformatics Division, BNRIST 
xl-zhang15@mails.tsinghua.edu.cn 
Fang Huan Department of Automation, Center for Synthetic and Systems Biology, Tsinghua University
Ministry of Education Key Laboratory of Bioinformatics
Bioinformatics Division, BNRIST 
 
Wang Xiao-Wo Department of Automation, Center for Synthetic and Systems Biology, Tsinghua University
Ministry of Education Key Laboratory of Bioinformatics
Bioinformatics Division, BNRIST 
xwwang@tsinghua.edu.cn 
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Abstract:
      The investigation about chromatin 3D structure is becoming one indispensable way in studying genome functions and gene regulation. In past several years, thanks to the development of chromatin conformation capture technology and decreasing cost of high throughput sequencing, the amount of whole-genome interaction data increases rapidly with the ascending resolutions. This not only brought the chances for interpreting 3D genome, but also challenged the modeling methods. Nowadays, methods of analyzing these data covered a range wide, including pre-processing, normalization, visualization, features extraction and 3D modeling; however, choosing efficient and precise computational methods becomes an obstacle limiting the study of 3D genome. In this paper, we sum up these methods according to their suitable conditions, principles and characters and focus on the methods for new technologies and requirements in order to promote the application and development of these methods, assisting the investigation of 3D genome.
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