对象名 't_year_quarter' 无效。a
Li Mi,Xi Ning,Wang Yuechao,Liu Lianqing.Applications of Multiparametric Imaging Atomic Force Microscopy in Probing Cellular and Molecular Mechanics*[J].Progress in Biochemistry and Biophysics
Applications of Multiparametric Imaging Atomic Force Microscopy in Probing Cellular and Molecular Mechanics*
Received:April 22, 2018  Revised:June 17, 2018
Key words:atomic force microscopy, multiparametric imaging, mechanics, cells, molecules
Fund:国家自然科学基金(61503372, 61522312, U1613220, 61433017, 91748212);中国科学院青年创新促进会(2017243);中国科学院、国家外国专家局创新团队国际合作伙伴计划资助项目.
Author NameAffiliationE-mail
Li Mi Shenyang Institute of Automation, Chinese Academy of Sciences limi@sia.cn 
Xi Ning Shenyang Institute of Automation, Chinese Academy of Sciences  
Wang Yuechao Shenyang Institute of Automation, Chinese Academy of Sciences  
Liu Lianqing Shenyang Institute of Automation, Chinese Academy of Sciences  
Hits: 319
Download times: 98
Abstract:
      The advent of atomic force microscopy (AFM) provides a powerful tool for probing the physical properties of native biological samples with unprecedented spatiotemporal resolution at the micro/nanoscale, significantly complementing traditional biochemical assays. In recent years, multiparametric imaging AFM, which is able to simultaneously obtain the topographical features and multiple mechanical properties (e.g., Young's modulus, adhesion, and deformation) of biological samples, emerges as a new method for investigating the correlations between structure, mechanics and functions of biological systems. The biomedical applications of multiparametric imaging AFM have yielded considerable novel insights into cellular/molecular activities and the underlying mechanisms guiding pathological processes. In this paper, based on our own research in single-cell detection using AFM, the principle of multiparametric imaging AFM is presented and the progress in utilizing multiparametric imaging AFM to probe cellular and molecular mechanics is summarized. The challenges and future directions are also discussed.
Download PDF  View/Add Comment  Download reader
  
©:Progress in Biochemistry and Biophysics
Responsible Institution:中国科学院Organizers:Institute of Biophysics, The Chinese Academy of Sciences; Biophysical Society of ChinaAddress:15 Datun Road, Chaoyang District,Beijing 100101,China
Tel:010-64888459Email:prog@sun5.ibp.ac.cn
Support:Beijing E-Tiller Co.,Ltd.