Lipoproteins are a kind of cell membrane anchoring proteins widely found in Gram-negative bacteria and Gram-positive bacteria, which possess many biological functions. Lipoproteins are not only as virulence factors, but also can recognize and elicit the host's immune system, which becomes one of the most popular research targets for the prevention and treatment of bacterial infection. This paper reviews the research progress of lipoprotein functions, and their application as vaccine candidates or drug targets in Streptococci. The prospect and suggestion are provided for the future research on Streptococci lipoprotein, which will expand research ideas for lipoprotein in Streptococci.