跨时间尺度的神经电磁活动
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作者单位:

1.山东大学集成电路学院;2.山东大学齐鲁医院妇产科生殖医学中心;3.山东大学基础医学科学院生理学系;4.山东大学基础医学院

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中图分类号:

Q42;R338;TP183

基金项目:

国家自然科学基金(12204273)和山东省自然科学基金(ZR2024MF107)资助项目。


Neuroelectromagnetic Activities Across Temporal Scales
Author:
Affiliation:

1.School of Integrated Circuits, Shandong University;2.Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University;3.Department of Physiology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University

Fund Project:

This work was supported by grants from The Natural Science Foundation of China (12204273) and the Natural Science Foundation of Shandong Province, China (ZR2024MF107).

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    摘要:

    尽管全球脑科学研究日新月异,但神经科学领域的一些基础性关键问题依然悬而未决。例如,神经信号传递的机制仍存在争议,在神经信息的载体、存储与检索等方面也尚未完全阐明。需要从多元角度,对神经信号的生成、传递、整合、存储及检索等信息处理系列过程进行梳理。显而易见,这些神经电磁活动的持续特性和动态变化模式与时间紧密相关(简称“时程”)。本文将从“时程”维度,审视神经信号处理不同阶段所需的时间及相应的特征,并进而阐述我们对神经电磁信号传递机制,以及神经信号载体与记忆的观点。在此基础上,本文提出了神经信号的物理载体更可能是持续时间处于微秒量级的瞬态电磁脉冲,而动作电位更可能是这一电磁过程在膜电生理层面的外在表现;同时,认为长期记忆更可能存储于由电突触连接形成的神经网络拓扑结构之中,而非单一或某几个突触权重本身。本文强调电磁学在神经活动中的作用应被高度重视并深入探究,这有望为神经编码与调控、大脑工作机制与记忆存储等基础及应用脑研究,提供宝贵且具参考价值的全新视角。

    Abstract:

    Although global brain science research has progressed rapidly in recent decades, several fundamental questions in neuroscience remain unresolved. In particular, the physical mechanism underlying neural signal transmission remains controversial, and the carriers responsible for neural information storage and retrieval have not yet been fully clarified. These unresolved issues motivate us to re-examine the processes of neural information generation, transmission, integration, storage, and retrieval from multiple perspectives. A key observation is that neural electromagnetic activities are closely associated with time. Their duration, temporal structure, and dynamic evolution play crucial roles in neural information processing. In this work, we analyze neural electromagnetic activities from the perspective of temporal scales (referred to here as the "time course"). By reviewing and integrating findings from previous studies, we examine the characteristic time requirements and dynamic features of neural processes occurring at different stages of information processing. These stages include neural signal generation, signal transmission along axons, synaptic integration, synaptic plasticity, and memory formation and retrieval. Based on this temporal analysis, we outline a framework describing neural electromagnetic activities across a wide range of time scales, spanning from microseconds to minutes, hours, or even longer periods associated with long-term memory, which suggests that neural information processing involves multiple physical processes operating at different time levels. Rapid electromagnetic events may occur on microsecond scales, whereas electrophysiological phenomena such as action potentials typically last on the order of milliseconds. Longer time scales are associated with synaptic plasticity and memory-related processes. From this perspective, we propose that the physical carrier of neural information may be transient electromagnetic pulses with durations on the microsecond scale. In this framework, action potentials can be interpreted as the macroscopic electrophysiological manifestation of underlying electromagnetic processes triggered by ionic currents across neuronal membranes. Rather than being the fundamental neural signal itself, the action potential may represent a measurable membrane-level response associated with the successful activation of these electromagnetic events. Moreover, we discuss a possible mechanism for long-term memory storage. Considering the apparent temporal contradiction between the millisecond-scale excitation of neurons and the long-term persistence of memories, we believe that long-time memory information may be stored within neural network topologies formed by electrical synapse coupling. Such structures, referred to as electrically coupled memory networks (ECMNs), may enable neurons within the same network to respond rapidly and synchronously to stimuli, thereby facilitating efficient memory retrieval. Overall, this study emphasizes the importance of considering the temporal organization of neural electromagnetic activities when interpreting neural signaling mechanisms. It may provide new insights into the physical nature of neural information carriers and the mechanisms of memory storage and retrieval. Furthermore, highlighting the potential role of electromagnetic interactions in neural activity may contribute to the development of new theoretical frameworks and experimental approaches in neuroscience. Such perspectives may also offer valuable references for future research on neural coding, brain function mechanisms, and neuromodulation technologies.

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沈卓群,徐小飞,王艳青,李景新,田&#; 岚,郭&#; 炜,徐晶晶.跨时间尺度的神经电磁活动[J].生物化学与生物物理进展,,():

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  • 收稿日期:2025-11-04
  • 最后修改日期:2026-04-27
  • 录用日期:2026-04-27
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