Parkinson"s disease (PD) is a neurodegenerative disease in which the level of DA in striatum is continuously reduced due to the apoptosis of dopaminergic neurons in the substantia densa nigra (SNpc). The main clinical manifestations are static tremor, myotonia, and bradykinesia. The striatum is an important center in the regulation of subcortical motor function, which is regulated by several signaling pathways. Medium multispinous neurons are one of the key neurons in the striate. The dopamine receptor type 2 medium multispinous neurons (D2-MSNs), which account for half of MSNs, play a key role in motor regulation. The abnormal function of D2-MSNs is thought to be related to the development of PD motor dysfunction. The extracellular signal-regulated kinase/mitogen-activated protein kinase (Erk/MAPK) signaling pathway is pathologically altered in PD, further leading to decreased D2-MSNs activity. Exercise intervention is considered as a potential therapeutic strategy for PD, and recent studies have shown that exercise can enhance the activity of D2-MSNs by inhibiting the Erk/MAPK signaling pathway. However, the specific role of Erk/MAPK signaling pathway in exercise intervention to alleviate PD motor dysfunction is still unknown. Therefore, this paper aims to explore the relationship between Erk/MAPK signaling pathway in striatal neurons and PD motor prevention and treatment, and provide scientific basis for finding new targets for PD treatment.