MAR (matrix association regions)是真核基因组的DNA序列中可特异性地与核基质紧密结合的区域.MAR通过特异性地与一些MAR结合蛋白相互作用，在真核基因的复制和表达调控以及染色体的包装构建等方面发挥重要作用.MAR结合蛋白主要包括一些构成染色质或核基质的结构蛋白（如组蛋白H1、拓扑异构酶Ⅰ和Ⅱ、HMG I/Y、Lamin B1、Matrin等）以及一些组织特异性表达的蛋白（如SATB1、骨钙蛋白基因启动子结合因子等）.根据它们与核基质的关系将MAR结合蛋白分为三类：核基质富含组分、核基质稀有组分以及非核基质组分，对其与MAR的相互作用进行了比较和分析.
Abstract:
Matrix association region (MAR) is the DNA sequences in eukaryotic genome which can specifically associate with the nuclear matrix. By means of specific interaction with some MAR-binding proteins, MAR plays important roles in eukaryotic gene's replication, expression and regulation, and chromosomal construction. MAR-binding proteins include some structural proteins in chromatin or nuclear matrix (such as histone H1, topoisomerase Ⅰ & Ⅱ, HMG I/Y, lamin B1, and matrins.) and some tissue-specifically expressed proteins, including SATB1 (special AT-rich binding protein 1) and osteocalcin gene promoter-binding factors. By the relationship with the nuclear matrix, these MAR-binding proteins can be classified in three groups, nuclear matrix-abundant composition, rare composition and non-nuclear matrix composition. Their interactions with MARs were compared and analyzed as well.
