Content of DNA, rasp21 and p53 in 80 case gastric precancer lesion was quantitative detected by flow cytometry and immunofluorescence techniques. and to investigate its in clinical value as early carceration marker.The detected results showed that raising in DNA heteroploid rate. Rasp21 and p53 protein expression were found with raising of dysplasia grade in gastric precancer lesion. The rate of canceration of gastric precancer lesionin in DNA heteroploid and rasp21 expression positive were notable increased. DNA heteroploid and rasp21 protein over-expression can be an early canceration molecular marker.