国家自然科学基金资助项目(10075007)、河北省自然科学基金项目(198027)和河北省博士基金项目(00547001D).
This work was supported by grants from The National Natural Sciences Foundation of China (10075007), Hebei Provincial Nature Science Foundation (102001) and Doctoral Fund of Hebei Province (00547001D).
用主方程方法研究分子马达一维周期性四态不等间距随机跃迁模型,得出稳态情况下分子马达的漂移速度V、扩散系数D及随机参数r,将三者随ATP的浓度[ATP]及外力F的变化进行了曲线拟合,并同大量实验结果进行了比较,定性半定量地分析了分子马达在拖动负载运动时的动力学行为.
The stochastic master equation approach to molecular motor's directed motion is used and a periodic one-dimensional four-state stochastically unequal interval hopping model is studied. The drift velocity V, the diffusion constant D and the randomness parameter r of the steady state are all be obtained. By comparing the simulated curve with experiment about drift velocity V, diffusion constant D and randomness parameter r versus [ATP] and external load F, the kinetic behaviors of a molecular motor under external load F are qualitatively analyzed.
展永,吴魏霞,赵同军,关荣华,梅俊平.分子马达不等间距四态跃迁模型[J].生物化学与生物物理进展,2003,30(3):416-421
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