国家自然科学基金资助项目(30025023,30270363,30130230,30470448),国家重点基础研究资助项目(G1666054000,2004CB720000),中国科学院知识创新工程项目(KSCX2-SW-224)和李氏基金和中德科学中心.
This work was supported by grants from The National Natural Sciences Foundation of China (30025023,30270363,30130230,30470448), The National Basic Research Program of China (G1666054000,2004CB720000), The Chinese Academy of Sciences Project (KSCX2-SW-224), The Li Foundation and the Sinogerman Scientific Center.
大电导的电压和 Ca2+ 激活的 K+ 通道 (BK 通道 ) 在哺乳动物的组织中广泛表达,起着多种多样的作用 . 目前只有少数组织中 BK 通道的性质被深入地研究,而且鲜见有失活的 BK 通道 (BKi) 的报道,尤其是在神经元中 . 发现在大鼠小直径的背根神经节 (DRG) 神经元中,普遍存在失活的 BK 通道 . 失活的 BK 电流成分是 Ca2+敏感的,可以被大电导的 BK 通道特异阻断剂 ChTX 所阻断,而且木瓜蛋白酶可以从胞外改变通道失活的特性 .
Large conductance voltage and Ca2+-activated K+ channels (BK channels) , which are ubiquitously expressed among mammalian tissues, play a variety of physiological roles. The inactivating BK channels have not been extensively studied in primary tissues and rarely do they exhibit inactivation. An inactivating BK current (BKi) was identified in rat small dorsal root ganglia (DRG) neurons . The inactivating currents are sensitive to the specific BK channel blocker charybdotoxin (ChTX) and the effect of ChTX can be removed partially when washed with normal external solution. The inactivation of BKi can be removed by external treatment of papain.
李 伟,万 有,韩济生,丁久平,徐 涛.大鼠背根神经节神经元上失活 BK 通道特性的研究[J].生物化学与生物物理进展,2005,32(5):408-412
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