Epithelial surfaces of the upper alimentary tract and upper respiratory tract are swarming with protein compounds that protect itself from many kinds of damages. These compounds are consisted of innate immune molecules. From the structure and functional prediction, the new member is added, PLUNC family, to the compounds. They are including at least ten members. SPLUNC1 (short palate, lung, and nasal epithelium clone 1) is isolated from human nasopharyngeal epithelia by suppression subtractive hybridization (SSH) and cDNA microarray analysis in our lab. SPLUNC1 is a gene transcript of the PLUNC gene family and also is a member of the BPI (bactericidal permeability increasing protein)/LBP(lipopolysaccharide-binding protein) family with putative bactericidal/bacteriostatic functions. They may function to protect epithelial surfaces from pathogenic micro-organism and harmful gases, the wrong expression will lead to host tissues destruction and tumorigenesis.