山药中的致痒物质及致痒机制研究

doi:10.16476/j.pibb.2019.0046

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山药中的致痒物质及致痒机制研究
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                        10.16476/j.pibb.2019.0046
                    
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作者单位:1.1)南京中医药大学医学与生命科学学院，精神疾病与中医药防治重点实验室，南京 210023;2.2)南京中医药大学药学院，南京 210023;3.3)江苏省植物研究所，南京 210014;4.4)中国科学院微生物研究所，北京 100101
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基金项目:国家自然科学基金（3147100）和南京中医药大学青年基金（13XZR0）资助项目.

Study on Itching Substance and Mechanism in Chinese Yam(Dioscoreae Rhizoma)

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1.1)School of Medicine and Life Sciences, and Key Laboratory of Chinese Medicine for Prevention and Treatment of Neurological Diseases, Nanjing University of Chinese Medicine, Nanjing 210023, China;2.2)Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;3.3)Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China;4.4)State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

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This work was supported by grants from The National Natural Science Foundation of China (3147100） and Youth Fund of Nanjing University of Chinese Medicine (13XZR01).

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山药是一种传统中药，对人体有许多益处，如抗腹泻、抗炎、抗糖尿病、低胆固醇血症、抗氧化、抗肿瘤和免疫调节. 山药黏液接触皮肤，常引起严重瘙痒. 而山药中存在的致痒物质成分尚不清楚. 我们采用乙醇提取、膜过滤、离子交换色谱、悬浮液滴法从新鲜山药中提取尿囊素晶体. 从河南焦作山药中提取的尿囊素含量约为3.567 mg/g. 活性实验结果表明，尿囊素引起的小鼠抓挠反应次数显著地高于对照组. 尿囊素直接激活背根神经节神经元，诱导钙流入，还可以诱导神经元内向电流产生. 我们首次在细胞水平证明尿囊素能够激活神经细胞，诱导痒觉信号传导.关键词山药，尿囊素，钙离子内流，背根神经节中图分类号 Q189 DOI: 10.16476/j.pibb.2019.0046

Abstract:

Chinese yam is a traditional Chinese medicine. It has many benefits for people, such as antidiarrhea, anti-inflammation, antidiabetic, hypocholesterolemia, antioxidation, antitumor, and immunomodulation. However, in the process of contacting yam, it often causes itching. However, the pruritus compound in yam is very unclear. We extract allantoin crystal from fresh Chinese yam using ethanol extraction, membrane filtration, ion exchange chromatography, suspension drop method. The content of allantoin extracted from yam (origin from Jiaozuo, Henan) is about 3.567 mg/g. Allantoin is an important compound in plants and animals. Our results show that allantoin could induce more scratch numbers in mice than control group. Allantoin also directly actives dorsal root ganglia neurons, induces calcium influx and inward current in neurons.

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杨雁,孙羽灵,刘培,钱林楠,关东朗,简暾昱,朱婵,于光,王长明,朱静,李德峰,唐宗湘.山药中的致痒物质及致痒机制研究[J].生物化学与生物物理进展,2019,46(10):1012-1019

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收稿日期:2019-03-13
最后修改日期:2019-07-21
接受日期:2019-07-24
在线发布日期: 2020-03-04
出版日期: 2019-10-20

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