1.1)广西大学电气工程学院,南宁 530004;2.2)广西医科大学生物医学工程系,南宁 530021;3.3)广西大学计算机与电子信息学院,南宁 530004
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广西自然科学基金项目
1.1)College of Electrical Engineering, Guangxi University, Nanning 530004, China;2.2)Department of Biomedical Engineering,Guangxi Medical University, Nanning 530021, China;3.3)School of Computer and Electronic Information, Guangxi University, Nanning 530004, China
Natural Science Foundation of GuangXi Province, China
稳态视觉诱发电位(steady-state visual evoked potential, SSVEP)在大脑的感知、认知研究中具有广泛应用。目前,对SSVEP次谐波的诱发机制尚未清楚。为此,本文通过视皮层网络模型进行SSVEP次谐波的诱发因素和功率变化的研究;进一步,测试20名受试者的头表SSVEP,对建模仿真结果进行验证。仿真和实验结果表明,刺激频率、刺激强度和噪声强度是影响SSVEP的1/2次谐波诱发和功率变化的三个重要参数。次谐波诱发是三个参数协同作用的结果:(1)在刺激频率和噪声强度相同时,1/2次谐波功率随刺激强度的变化曲线与Sigma函数相似,存在无诱发区、线性增长区和饱和区:在无诱发区,1/2次谐波功率近似为0;在线性增长区,1/2次谐波功率和刺激强度成正比;在饱和区,1/2次谐波功率趋于恒定;(2)在噪声强度相同时,能明显诱发出1/2次谐波的刺激参数区域呈现非线性同步中的阿诺德舌头变化规律,即能诱发1/2次谐波的有效刺激频率范围随刺激强度的增大而增宽;(3)在刺激参数相同时,噪声强度的大小决定了1/2次谐波能否被诱发;噪声强度越大,对1/2次谐波的诱发及功率抑制作用就越强。本文的实验和仿真结果基本一致,说明了模型仿真的可行性。研究结果为理解SSVEP次谐波的产生机制及其有效应用提供有意义的理论和实验依据。
Steady state visual evoked potential (SSVEP) is widely used in the study of brain perception and cognition. At present, the mechanism of SSVEP subharmonic is ambiguous. The induced factors and power variation of the SSVEP subharmonics is studied by a visual cortex network model in this paper. Further, the SSVEP of 20 subjects’ head surface is tested to verify the simulation results. The simulation and experimental results show that the stimulus frequency, stimulus intensity and noise intensity are three important parameters that affect the 1/2 subharmonic induction and power change of SSVEP. Subharmonic is induced by the synergistic action of three parameters: (1) when the stimulus frequency and noise intensity are same, the curve of 1/2 subharmonic power with stimulus intensity is similar to sigma function, and there are non-induction region, linear growth region and saturation region: in non-induction region, 1/2 subharmonic power is approximately 0; in linear growth region, 1/2 subharmonic power is proportional to stimulus intensity; in saturation region, 1/2 subharmonic power is proportional to stimulus intensity; when the noise intensity is same, the stimulus parameters area that can induce the 1/2 subharmonic obviously is similar with arnold tongue in nonlinear synchronization, that is, the effective stimulus frequency range widen with the increase of stimulus intensity; (3) when the stimulus parameter is same, the noise intensity determines the 1/2 subharmonic energy ; the higher the noise intensity is, the stronger restraining effect of inducing 1/2 subharmonic and power is. The experiment and simulation results in this paper are basically consistent, which shows the feasibility of model simulation. The research results provide theoretical and experimental basis for understanding the generation mechanism and effective application of SSVEP subharmonics.
陈 妮,覃玉荣,高欢,黎钰钦,孙鹏飞. SSVEP次谐波的诱发影响因素及其功率变化——建模及实验研究*[J].生物化学与生物物理进展,2020,47(9):999-1011
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