Atherosclerosis, as a major cardiovascular disease, threatens the health of humans worldwide. Currently, drug-eluting stent implantation is the most effective treatment to enlarge the lumen of an artery narrowed by an atherosclerotic lesion. However, drug-eluting stent implantation has several disadvantages, including the onset of late stent thrombosis, neo-atherosclerosis, and local inflammation caused by the presence of a foreign body. To overcome these limitations, bioresorbable scaffolds have been developed for use as transient scaffolds for blood vessels. Fully bioresorbable polymer intravascular scaffolds are made of high biodegradable molecular polymers. At the same time, because of the stimulation of degradation products at all levels and the changes in the mechanical microenvironment of the stent implantation site, the full degradable polymer stents can cause the inflammatory response, the in-stent restenosis and thromboembolism. We combine mechanical growth factor (MGF) with local mechanics changes caused by bioresorbable scaffolds. Therefore, this paper reviews the effect between the degradation characteristics and the mechanical microenvironmental changes of fully polymer bioresorbable scaffolds implantation, as well as the research progress of MGF in cardiovascular diseases, in order to provide references for the clinical intervention of fully bioresorbable polymer intravascular scaffolds therapy.