Here, we review nitric oxide (NO) free radical as a driving force for Qi-blood circulation; antioxidants’ scavenging oxygen free radicals, protecting NO and helping NO to drive Qi-blood circulation, as well as their protecting cardiovascular and cerebrovascular health together with NO. NO and natural antioxidants can improve the longevity, and synergistically eliminate the damage caused by inflammation. Traditional Chinese medicines (TCM) including natural antioxidants ensure health via activating Qi-blood circulation and removing blood stasis, in which NO plays an important role in the invigoration of Qi-blood circulation.