In previous studies, it was found that blocking the low hydraulic resistance channel (LHRC) along meridian in mini-pigs could lead to the hyperalgesia, a series of abnormal behavioral changes, traditional Chinese medicine (TCM) syndromes and abnormal autopsy in internal organs. The objective of this paper is to investigate the pathology of these changes. Mini-pigs were randomly divided into a stomach meridian blocking group (SBG, n=8), a kidney meridian blocking group (KBG, n=8) and a control group (CG, n=6). The hydraulic gel was injected separately into LHRCs along the stomach meridian and the kidney meridian. The pigs were then fed 7 to 9 weeks, and several indexes were observed. The results showed that the blood serum creatinine increased extremely in all 3 groups and the level in the KBG was lower than that in the SBG by 13.76% (p＜0.05) and in the CG by 14.51% (p＜0.01). HE staining results showed that more than half of the pigs had the heart abnormalities in the CG, the liver abnormalities in the SBG and the kidney and testicles abnormalities in the KBG. Intestinal sections in the SBG showed that the intestinal crypt depth of the duodenum and the colon, and the total mucosal thickness of the large intestine were significantly higher than those of the CG. The jejunal V/C and the ileal crypt depth were significantly lower than those of the KBG, and the ileal V/C was significantly higher than that of the KBG. Compared with the CG, intestinal sections of the KBG showed that the duodenal crypt depth and the thickness of the colon was significantly higher than that of the CG. The GAS in the KBG was significantly higher than those of the CG and the SBG. The results verify that the blockage of LHRC along the stomach meridian and the kidney meridian can lead to different pathological phenomena, which provided a scientific basis for the syndromes induced by meridian stasis.