2型糖尿病相关继发认知损害障碍及中药的治疗机遇

doi:10.16476/j.pibb.2020.0265

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2型糖尿病相关继发认知损害障碍及中药的治疗机遇
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                        10.16476/j.pibb.2020.0265
                    
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作者单位:1.1)西南医科大学附属中医医院/药学院/中葡中医药国际合作中心，泸州 646000;2.2)中国医学科学院北京协和医学院药用植物研究所，北京 100193;3.3)Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;4.4)中国航天员科研训练中心人因工程国家重点实验室，北京 100094;5.5)湖南省药物安全评价研究中心，长沙 410331
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From Type 2 Diabetes toRelated Cognitive DysfunctionImpairment and Therapy Opportunities withof Traditional Chinese Medicines

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1.1)Affiliated TCM Hospital/School of Pharmacy/Sino-Portugal TCM International Cooperation Center, Southwest Medical University, Luzhou 646000, China;2.2)Research Center of Pharmacology and Toxicology, Peking Union Medical College, Institute of Medicinal Plant Development, Beijing 100193, China;3.3)Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;4.4)National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing 100094, China;5.5)Hunan Provincial Research Center for Safety Evaluation of Drugs, Changsha 410331, China

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摘要:

糖尿病是影响多个器官生理机能的最具毁灭性的代谢紊乱疾病之一。 2型糖尿病(T2D)通常影响老年人群，也是世界上最普遍的糖尿病类型。。 T2D通常影响老年人群，临床研究表明，T2D与认知功能损害，下降尤其是学习记忆能力功能下降有关。与正常人群相比，T2D患者继发患痴呆症的风险较高。本文综述了近年来有关 T2D患者认知损害功能下降和动物模型方面的研究，包括以及相关的机制和、治疗方法、中药治疗的可能性机遇，以期对T2D认知并并发认知损害发症有更深入好的认识。

Abstract:

Diabetes mellitus is one of the most devastating metabolic disorders affecting physiology of several organs. Type 2 diabetes (T2D) is the most prevalent type of diabetes worldwide, and . T2D usually affects elder population. and cClinical and basic studies have highlighted its involvement in cognition decline especially learning and memory. T2D individuals are at high risk to develop dementia as compare to normal population. This paper reviews highlighted the recent studies which demonstrated cognitive decline among T2D individuals and in animal models, including the related mechanisms and, the therapies, to make a better knowledge on T2D cognitive complication.

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Ayaz Ahmed,李玉姣,李杉杉,魏山山,王孟迪,杨思进,陈善广,曾贵荣,Mudassar Azhar,刘新民,王琼.2型糖尿病相关继发认知损害障碍及中药的治疗机遇[J].生物化学与生物物理进展,2020,47(8):743-761

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收稿日期:2020-07-27
最后修改日期:2020-07-27
接受日期:2020-07-27
在线发布日期: 2020-11-26
出版日期: 2020-08-20

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