The TANK-binding kinase 1(TBK1) is a serine and threonine kinase. It plays important roles in regulating biological functions of the body, such as sequestering the innate immunity, modulating the cell selective autophagy, regulating the apoptosis, and monitoring the cell regeneration. These mechanisms emphasize that TBK1 is inseparable from tumors, which also means inhibiting the biological function of TBK1 may induce an antitumor immune response. The circle RNA (circRNA) is a novel class of the no-coding RNA with the fixed loop structure and proved to influence on many kinds of tumor, such as gastric cancer, lung cancer, colon cancer and liver cancer, attracting the widespread concern from the scholars. Recent evidence suggests TBK1 interacts with circRNA directly, affecting the developments and the differentiation of the tumor cell. These analyses have showed the interaction between TBK1 and circRNA, which can promote the formation of cytokines and chemokines in the tumor microenvironment, reflecting the great potential of them in the tumor targeted therapy. In order to analyze their interation patterns and shed new light on the tumor targeted therapy, this paper summarizes the research on TBK1 and circRNA in tumors in the past 10 years.