Bio-derived materials, such as collagen, gelatin, fibrinogen, cellulose, starch and chitosan etc, are attracting more and more attention for being used as hemostatic materials due to their excellent biocompatibility, biodegradability and procoagulant activity. This review discusses several types of hemostatic materials and the corresponding hemostatic mechanisms. Our focus is tailored towards the basic structure, hemostatic mechanism, commercial products and the latest scientific research progress of the above-mentioned bio-derived hemostatic materials. Finally, the tendencies of their development are prospected.