Conditional gene-editing system can limit gene modification occur in specific tissues or organs at a specific time, which can be realized by introducing conditional gene deletion system and conditional gene overexpression system into animals, and has been widely used in the study of gene function in mice. Gene-editing pigs have important application value in agriculture and biology. In the field of biological medicine, because of the similarities of body, organ size, physiology, metabolism, and life with humans, genetically-modified pigs can be used for the basic research of gene function, and as a model of human disease, xenotransplantation supply and human functional protein bioreactor. Benefit from the development of gene editing technology in recent years, it is possible to introduce the conditional gene expression system in pigs, and conditional gene expression pig model will greatly promote the research progress. In this paper, we review the progress in the construction of conditional modification systems and genetically-modified pig models by using gene editing techniques.