首页 > 过刊浏览>2022年第49卷第12期 >2328-2341. DOI:10.16476/j.pibb.2022.0302
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外泌体对睾丸微环境调控机制研究及应用进展
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1) 湖南中医药大学中西医结合学院，长沙 410208;2) 湖南中医药大学男科实验室，长沙 410208;3) 湖南中医药大学第一中医临床学院，长沙 410208;4) 湖南医药学院，怀化 418000;5) 广西中医药大学科学实验中心，南宁 530200;6.6) 湖南中医药大学第一附属医院，长沙 410007

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基金项目:

国家自然科学基金（82074444，81673984），湖南创新型省份建设专项经费资助-“湖湘青年英才”支持计划（2019RS2041），湖南省教育厅重点项目（20A368），长沙市科技计划项目经费资助-长沙市杰出创新青年培养计划（kq1802015），湖南省高层次卫生人才225工程医学学科骨干人才培养对象（湘卫函［2019］196号），中华中医药学会“青年人才托举工程”（2019-QNRC2-C07），湖南中医药大学中西医结合一流学科开放基金（2020ZXYJH64）和湖南中医药大学研究生创新课题（2022CX09）资助项目。


Research on The Regulation Mechanism of Exosomes on Testicular Microenvironment and Its Application Progress
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Affiliation:

1) College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China;2) Andrology Laboratory, Hunan University of Chinese Medicine, Changsha 410208, China;3) The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China;4) Hunan Medical College, Huaihua 418000, China;5) Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China;6.6) The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (82074444, 81673984), the Special Funds for the Construction of Innovative Provinces in Hunan - “Huxiang Young Talents” Support Program (2019RS2041), the Key Projects of Hunan Provincial Department of Education (20A368), Changsha Science and Technology Plan Project—Changsha Outstanding Innovative Youth Training Program (kq1802015), the Hunan Province High-level Health Talents 225 Engineering Medical Discipline Backbone Talent Training Object (Xiang Wei Han [2019] 196), the China Association of Traditional Chinese Medicine “Young Talent Support Project” of the China Association of Chinese Medicine (2019-QNRC2-C07), the Hunan University of Chinese Medicine First-class Discipline of Integrated Chinese and Western Medicine Open Fund (2020ZXYJH64), and the Hunan University of Chinese Medicine Graduate Innovation Project (2022CX09).

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    摘要:

    外泌体（exsomes）是一类具有生物活性的双层脂质组成的小囊泡，可携带不同类型的信息物质与受体细胞结合，通过信息传递与物质交换，促发受体细胞的表型发生变化。本文总结了在睾丸微环境中，外泌体通过调节细胞因子促进睾丸微环境中细胞增殖、调节细胞免疫维持睾丸免疫环境、调节氧化应激修复受体细胞功能、调节细胞自噬改善生精能力、调节细胞凋亡改善精子发生、调节细胞因子影响睾酮分泌等机制维持睾丸微环境稳态，并对外泌体在男科相关疾病预防、诊断、治疗中的作用进行归纳，外泌体在男性不育、勃起功能障碍、精索静脉曲张、性腺功能减退、前列腺癌等疾病诊疗中具备明显优势。外泌体作为一种新兴的应用物质，随着外泌体工程和提取工艺的不断优化，以及相关机制研究的不断深入，外泌体在男科疾病中的临床运用成为可能，有望成为治疗男科疾病的新手段。

    Abstract:

    Exosomes are a class of small vesicles composed of bioactive bilayer lipids, which can carry different types of information substances and bind to recipient cells. Through information transmission and substance exchange, exosomes can induce changes in the phenotype of recipient cells. This article summarized the various mechanisms of exosomes in maintaining testicular microenvironment homeostasis, such as promoting cell proliferation in the testicular microenvironment by regulating cytokines, regulating cellular immunity to maintain the testis immune environment, regulating oxidative stress to repair the recipient cell function, regulating autophagy to improve spermatogenesis, regulating cell apoptosis to improve spermatogenesis, and regulating cytokines to influence testosterone secretion. Then, the preventive, diagnostic and therapeutic effects of exosomes in andrology diseases were highlighted. Exosomes have obvious advantages in the diagnosis and treatment of infertility, erectile dysfunction, varicocele, hypogonadism, prostate cancer and other diseases. With the continuous advance in exosome engineering, exosome extraction, as well as research on the related mechanisms, the clinical application of exosomes, as an emerging applied substance, is expected to become a new treatment approach for andrological diseases.

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李波男,宁港,孙天松,吴悔,何清湖,唐乾利,周兴.外泌体对睾丸微环境调控机制研究及应用进展[J].生物化学与生物物理进展,2022,49(12):2328-2341

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历史
  • 收稿日期:2022-06-26
  • 最后修改日期:2022-10-19
  • 接受日期:2022-08-18
  • 在线发布日期: 2022-12-20
  • 出版日期: 2022-12-20
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