Lipid metabolism is one of the three major metabolisms in human body. Lipid metabolism is usually in a balanced state under the regulation of hormones and other signaling factors. When the homeostasis is disrupted, the level of triglyceride (TG) and cholesterol in the blood changes, eventually causing atherosclerosis (AS), obesity and other lipid dysfunction diseases. Long non-coding RNA (lncRNA) is a group of RNAs that do not have the ability to code proteins with more than 200 nucleotides in length. Recent studies have found that lncRNAs are closely related to the regulation of metabolism, inflammation, immune system, and vascular function. A large body of research suggests that lncRNAs are involved in the regulation of lipid metabolism and thus are expected to be potential therapeutic targets for some lipid metabolic diseases.