Colorectal cancer (CRC) is the second leading cause of cancer death, and patients tend to be more younger. Although chemotherapy, immunotherapy and targeted therapy have made progress, the toxicity, drug resistance and high price of drugs have seriously affected the comprehensive treatment effect of CRC. Therefore, seeking new, more sensitive and effective drugs and drug targets is the current research focus. Ferroptosis, a recently discovered regulation mode of cell death, which is closely related to cancer drug resistance. Activating ferroptosis has become a potential strategy to overcome the drug resistance mechanism of traditional cancer treatment. The development and application of drugs that induce ferroptosis is expected to become an effective means to treat CRC. This review describes the latest progress in the research of metabolic pathway drugs related to ferroptosis in CRC, so as to comprehensively understand the specific mechanism of ferroptosis based drugs in CRC, fully tap its therapeutic potential, and provide new methods for the diagnosis and treatment of CRC and the solution of drug resistance.